1-异吲哚啉羧酸盐酸盐(1:1)合成路线 （共 5 条）
参考文献
Lin, Linus S.; Shah, Shrenik K.; Chang, Linda L.; Hagmann, William K.; Mumford, Richard A.
Patent: US2002/193399 A1, 2002 ;
反应条件
sodium hydroxide
T=100°C; 30 h;
参考文献
New, J. S.; Yevich, J. P.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 1355 - 1360
反应条件
1.1: pyridinium p-toluenesulfonate / 2 h / 20 °C
2.1: boron trifluoride diethyl etherate / dichloromethane / 1 h / -78 °C / Inert atmosphere
3.1: water; sodium hydroxide / 3 h / 60 °C
3.2: 20 °C
4.1: hydrogenchloride; water; acetic acid / 72 h / Reflux
View Scheme
参考文献
Moran-Ramallal, Roberto; Gotor-Fernandez, Vicente; Laborda, Pedro; Sayago, Francisco J.; Cativiela, Carlos; Gotor, Vicente
Organic Letters, 2012 , vol. 14, # 7 p. 1696 - 1699
反应条件
1.1: boron trifluoride diethyl etherate / dichloromethane / 1 h / -78 °C / Inert atmosphere
2.1: water; sodium hydroxide / 3 h / 60 °C
2.2: 20 °C
3.1: hydrogenchloride; water; acetic acid / 72 h / Reflux
View Scheme
参考文献
Moran-Ramallal, Roberto; Gotor-Fernandez, Vicente; Laborda, Pedro; Sayago, Francisco J.; Cativiela, Carlos; Gotor, Vicente
Organic Letters, 2012 , vol. 14, # 7 p. 1696 - 1699
反应条件
hydrogenchloride; water; acetic acid
72 h; Reflux;
参考文献
Moran-Ramallal, Roberto; Gotor-Fernandez, Vicente; Laborda, Pedro; Sayago, Francisco J.; Cativiela, Carlos; Gotor, Vicente
Organic Letters, 2012 , vol. 14, # 7 p. 1696 - 1699
