N-苄基-2-(3,4-二甲氧基苯基)-N-甲基乙胺合成路线 （共 9 条）
反应条件
potassium iodide; NiCl2((PPh3)P)2; triphenylphosphine; zinc in N,N-dimethyl-formamide
T=55°C;
参考文献
Kihara, Masaru; Itoh, Joji; Iguchi, Seiichiro; Imakura, Yasuhiro; Kobayashi, Shigeru
Journal of Chemical Research, Miniprint, 1988 , # 1 p. 157 - 177
反应条件
1: Clemmensen reduction
2: 2.) NaBH4 / 1.) 120 deg C, 2.5 h, 2.) CHCl3, EtOH, r.t., 8 h
3: 1.) H3BO3, 2.) NaBH4 / 1.) CH3OH, H2O, r.t.
4: 16.4 percent / KI / Ni(PPh3)2Cl2-Zn-PPh3 / dimethylformamide / 55 °C
View Scheme
参考文献
Kihara, Masaru; Itoh, Joji; Iguchi, Seiichiro; Imakura, Yasuhiro; Kobayashi, Shigeru
Journal of Chemical Research, Miniprint, 1988 , # 1 p. 157 - 177
反应条件
1: 2.) NaBH4 / 1.) 120 deg C, 2.5 h, 2.) CHCl3, EtOH, r.t., 8 h
2: 1.) H3BO3, 2.) NaBH4 / 1.) CH3OH, H2O, r.t.
3: 16.4 percent / KI / Ni(PPh3)2Cl2-Zn-PPh3 / dimethylformamide / 55 °C
View Scheme
参考文献
Kihara, Masaru; Itoh, Joji; Iguchi, Seiichiro; Imakura, Yasuhiro; Kobayashi, Shigeru
Journal of Chemical Research, Miniprint, 1988 , # 1 p. 157 - 177
参考文献
Buck; Baltzly
Journal of the American Chemical Society, 1942 , vol. 64, p. 2263
反应条件
1: 2.) NaBH4 / 1.) 120 deg C, 2.) CHCl3, EtOH, r.t.
2: 1.) H3BO3, 2.) NaBH4 / 1.) CH3OH, H2O, r.t.
View Scheme
参考文献
Kihara, Masaru; Itoh, Joji; Iguchi, Seiichiro; Imakura, Yasuhiro; Kobayashi, Shigeru
Journal of Chemical Research, Miniprint, 1988 , # 1 p. 157 - 177
反应条件
1: 2.) NaBH4 / 1.) 120 deg C, 2.) CHCl3, EtOH, r.t.
2: 1.) H3BO3, 2.) NaBH4 / 1.) CH3OH, H2O, r.t.
View Scheme
参考文献
Kihara, Masaru; Itoh, Joji; Iguchi, Seiichiro; Imakura, Yasuhiro; Kobayashi, Shigeru
Journal of Chemical Research, Miniprint, 1988 , # 1 p. 157 - 177
反应条件
sodium tetrahydroborate; boric acid
1.) CH3OH, H2O, r.t.; Yield given. Multistep reaction;
参考文献
Kihara, Masaru; Itoh, Joji; Iguchi, Seiichiro; Imakura, Yasuhiro; Kobayashi, Shigeru
Journal of Chemical Research, Miniprint, 1988 , # 1 p. 157 - 177
反应条件
sodium tetrahydroborate; toluene-4-sulfonic acid
1) benzene, reflux, 2) MeOH; Multistep reaction;
参考文献
Casagrande; Santangelo; Saini; Doggi; Gerli; Cerri
Arzneimittel-Forschung/Drug Research, 1986 , vol. 36, # 2 A p. 291 - 303
反应条件
hydrogen bromide
3 h; Heating;
参考文献
Casagrande; Santangelo; Saini; Doggi; Gerli; Cerri
Arzneimittel-Forschung/Drug Research, 1986 , vol. 36, # 2 A p. 291 - 303
