2-溴-5,6-二氢噻吩并[2,3-c]吡啶-7(4H)-酮合成路线 （共 3 条）
反应条件
bromine; acetic acid T=0°C; 1 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/146758 A2, 2007 ;
Location in patent: Page/Page column 34 ;
WO 2007/146758 A2
反应条件
1.1: methanesulfonic acid; phosphorous pentoxide / 1 h / 20 °C 2.1: hydroxylamine hydrochloride; sodium acetate / methanol / 20 °C 2.2: Polyphosphoric acid Polyphosphoric acid Polyphosphoric acid polyphosphoric acid / 2 h / 130 °C 3.1: bromine; acetic acid / water / 1.5 h / 0 °C View Scheme
反应条件
1.1: hydroxylamine hydrochloride; sodium acetate / methanol / 20 °C 1.2: Polyphosphoric acid Polyphosphoric acid Polyphosphoric acid polyphosphoric acid / 2 h / 130 °C 2.1: bromine; acetic acid / water / 1.5 h / 0 °C View Scheme
