1,2-二羧基吡咯烷酸,4-羟基-1-[(4-硝基苯基)甲基]酯合成路线 （共 7 条）
反应条件
sodium hydroxide in dichloromethane T=0°C; Acylation; 2 h;
参考文献
Kang, Yong Koo; Shin, Kye Jung; Yoo, Kyung Ho; Seo, Kyung Jae; Hong, Chang Yong; Lee, Chang-Seok; Park, Seung Yong; Kim, Dong Jin; Park, Sang Woo
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 2 p. 95 - 99
反应条件
1: dioxane 2: aqueous NaOH; dioxane View Scheme
参考文献
Journal of the American Chemical Society, , vol. 74, p. 3818,3819
反应条件
1.1: triethylamine; isopropyloxycarbonylchloride / dichloromethane / -30 - -20 °C 2.1: triethylamine / dichloromethane / -20 °C 3.1: N,N-dimethyl-formamide / 70 - 80 °C 4.1: sodium hydroxide; water / methanol / 5 - 10 °C 4.2: pH 2 5.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / -25 °C 6.1: hydrogen / palladium on activated charcoal / ethyl acetate; water / 3-(N-morpholino)propanesulfonic acid buffer View Scheme
参考文献
ORCHID CHEMICALS AND PHARMACEUTICALS LIMITED; KARALE, Sanjay Nivrutti; JANGALE, Arvind Atamaram; KALDATE, Ram Dattatraya
Patent: WO2011/141847 A1, 2011 ;
反应条件
1.1: triethylamine; isopropyloxycarbonylchloride / dichloromethane / -30 - -20 °C 2.1: triethylamine / dichloromethane / -20 °C 3.1: N,N-dimethyl-formamide / 70 - 80 °C 4.1: sodium hydroxide; water / methanol / 5 - 10 °C 4.2: pH 2 5.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / -25 °C View Scheme
参考文献
ORCHID CHEMICALS AND PHARMACEUTICALS LIMITED; KARALE, Sanjay Nivrutti; JANGALE, Arvind Atamaram; KALDATE, Ram Dattatraya
Patent: WO2011/141847 A1, 2011 ;
反应条件
1.1: triethylamine; isopropyloxycarbonylchloride / dichloromethane / -30 - -20 °C 2.1: triethylamine / dichloromethane / -20 °C 3.1: N,N-dimethyl-formamide / 70 - 80 °C 4.1: sodium hydroxide; water / methanol / 5 - 10 °C 4.2: pH 2 View Scheme
参考文献
ORCHID CHEMICALS AND PHARMACEUTICALS LIMITED; KARALE, Sanjay Nivrutti; JANGALE, Arvind Atamaram; KALDATE, Ram Dattatraya
Patent: WO2011/141847 A1, 2011 ;
反应条件
1: sulfuric acid / 7 h / 60 °C 2: triethylamine / toluene / 0.33 h / 20 °C 3: sodium tetrahydroborate / ethyl acetate; methanol / 3 h / 0 - 5 °C View Scheme
参考文献
Nishino, Yutaka; Komurasaki, Tadafumi; Yuasa, Tetsuya; Kakinuma, Makoto; Izumi, Kenji; Kobayashi, Makoto; Fujiie, Shinichiro; Gotoh, Teruhiro; Masui, Yoshiyuki; Hajima, Makoto; Takahira, Masayuki; Okuyama, Akira; Kataoka, Takahiro
Organic Process Research and Development, 2003 , vol. 7, # 5 p. 649 - 654
反应条件
1: H2SO4 / 3 h / Heating 2: 97.1 percent / NEt3 / CH2Cl2 / 1 h / 0 °C View Scheme
参考文献
Nishino, Yutaka; Komurasaki, Tadafumi; Yuasa, Tetsuya; Kakinuma, Makoto; Izumi, Kenji; Kobayashi, Makoto; Fujiie, Shinichiro; Gotoh, Teruhiro; Masui, Yoshiyuki; Hajima, Makoto; Takahira, Masayuki; Okuyama, Akira; Kataoka, Takahiro
Organic Process Research and Development, 2003 , vol. 7, # 5 p. 649 - 654
