反应条件
1: Et3N / CH2Cl2 / 1 h 2: CH2Cl2 / 1 h 3: 86 percent / anisole, TiCl4 / CH2Cl2 / 1 h / 0 °C 4: 93 percent / γ-collidine / dimethylformamide / 1.5 h / 65 °C 5: 98 percent / Et3N / toluene / 5 h / Ambient temperature 6: 1.) NaH, 2.) benzyl bromide / 1.) THF, toluene, -20 deg C, 1 h, 2.) THF, toluene, -20 deg C, 2 h 7: DBU / toluene; tetrahydrofuran / 2 h 8: 89 percent / phosphate buffer pH 3 / 2.5 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 42, # 7 p. 1381 - 1387
