2-氯-5,6-二氟苯并噻唑合成路线 （共 3 条）
反应条件
thionyl chloride
T=50°C; 2 h;
参考文献
Ouyang, Liang; Huang, Yuhui; Zhao, Yuwei; He, Gu; Xie, Yongmei; Liu, Jie; He, Jun; Liu, Bo; Wei, Yuquan
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3044 - 3049
反应条件
1: hydrazine monohydrochloride; hydrazine hydrate / ethylene glycol / 2 h / 140 °C
2: thionyl chloride / 2 h / 50 °C
View Scheme
参考文献
Ouyang, Liang; Huang, Yuhui; Zhao, Yuwei; He, Gu; Xie, Yongmei; Liu, Jie; He, Jun; Liu, Bo; Wei, Yuquan
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3044 - 3049
反应条件
1: bromine; acetic acid / 0.5 h / 0 °C
2: hydrazine monohydrochloride; hydrazine hydrate / ethylene glycol / 2 h / 140 °C
3: thionyl chloride / 2 h / 50 °C
View Scheme
参考文献
Ouyang, Liang; Huang, Yuhui; Zhao, Yuwei; He, Gu; Xie, Yongmei; Liu, Jie; He, Jun; Liu, Bo; Wei, Yuquan
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3044 - 3049
