methanol; potassium permanganate in acetonitrile T=25°C; 0.5 h;

<b>Multi-step reaction with 7 steps<br /> </b>1: 65 percent / tetrahydrofuran; acetone / 1.) -15 deg C, 3h, 2.) 25 deg C, 18h<br />2: 100 percent / pyridine, hydroxylamine hydrochloride / methanol / 1 h / Heating<br />3: 95percent hydrazine hydrate / methanol / 72 h / Heating<br />4: 4 h / Heating<br />5: 1N HCl / trifluoroacetic acid / 0.33 h / 60 - 65 &deg;C<br />6: sodium dithionite / dimethylformamide; H₂O / 2 h / 60 - 65 &deg;C<br />7: 0.1 N NaOH / acetonitrile / 18 h / 25 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: 95percent hydrazine hydrate / methanol / 72 h / Heating<br />2: 4 h / Heating<br />3: 1N HCl / trifluoroacetic acid / 0.33 h / 60 - 65 &deg;C<br />4: sodium dithionite / dimethylformamide; H₂O / 2 h / 60 - 65 &deg;C<br />5: 0.1 N NaOH / acetonitrile / 18 h / 25 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 9 steps<br /> </b>1: 98 percent / tetrahydrofuran / 4 h / Heating<br />2: 77 percent / 1N NaOH / dimethylformamide; methanol / 18 h / 60 &deg;C<br />3: 65 percent / tetrahydrofuran; acetone / 1.) -15 deg C, 3h, 2.) 25 deg C, 18h<br />4: 100 percent / pyridine, hydroxylamine hydrochloride / methanol / 1 h / Heating<br />5: 95percent hydrazine hydrate / methanol / 72 h / Heating<br />6: 4 h / Heating<br />7: 1N HCl / trifluoroacetic acid / 0.33 h / 60 - 65 &deg;C<br />8: sodium dithionite / dimethylformamide; H₂O / 2 h / 60 - 65 &deg;C<br />9: 0.1 N NaOH / acetonitrile / 18 h / 25 &deg;C<br /> <br /> &nbsp;