4-甲基-2-氧代戊酸苄酯合成路线 （共 4 条）
反应条件
1: 4-methyl-2-oxopentanoic acid sodium salt With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=-20 - 20°C; 2 h;
2: benzyl alcohol With triethylamine in dichloromethane
T=0 - 20°C; 18 h;
参考文献
Chiesi Farmaceutici S.p.A.
Patent: US6344457 B1, 2002 ;
Location in patent: Page column 38 ;
US 6344457 B1
反应条件
in hexane; N,N-dimethyl-formamide
参考文献
Immunex Corporation
Patent: US5594106 A1, 1997 ;
US 5594106 A
反应条件
in chloroform; N,N-dimethyl-formamide
参考文献
Abbott Laboratories
Patent: US5268374 A1, 1993 ;
反应条件
pyridine; methanesulfonyl chloride in tetrahydrofuran
T=0 - 20°C; 18 h;
参考文献
Raimondi, Wilfried; Basle, Olivier; Constantieux, Thierry; Bonne, Damien; Rodriguez, Jean
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 4 p. 563 - 568
