3'-O-苄基-2'-脱氧-5-三氟甲基尿苷合成路线 （共 23 条）
反应条件
sodium hydrogencarbonate; tin(IV) chloride in methanol; hexane; dichloromethane; ethyl acetate; toluene; acetonitrile
参考文献
PCR, Inc.
Patent: US4898936 A1, 1990 ;
反应条件
tin(IV) chloride in ethanol; dichloromethane; ethyl acetate
参考文献
PCR, Inc.
Patent: US4898936 A1, 1990 ;
反应条件
tin(IV) chloride; sodium hydrogencarbonate in ethanol; ethyl acetate; toluene; acetonitrile
参考文献
PCR, Inc.
Patent: US4898936 A1, 1990 ;
反应条件
ammonium hydroxide in ethanol; acetone
2.5 h; Ambient temperature;
参考文献
Yamashita; Takeda; Matsumoto; Unemi; Yasumoto
Journal of Medicinal Chemistry, 1989 , vol. 32, # 1 p. 136 - 139
反应条件
1: 67 percent / pyridine / 0.33 h / 100 °C
2: 73 percent / sodium hydride (60 percent) / tetrahydrofuran / 1.5 h / Ambient temperature
3: 1.) pyridine, DMF, copper powder, 4-dimethylaminopyridine / 1.) < -70 to 115 deg C; sealed tube, 2.) 8 h, 60 deg C; sealed tube was opened
4: methanolic HCl (2 percent) / 2 h / Ambient temperature
View Scheme
参考文献
Yamashita; Matsumotot; Kobayashi; Noguchi; Yasumoto; Ueda
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 9 p. 2287 - 2292
反应条件
1: 73 percent / sodium hydride (60 percent) / tetrahydrofuran / 1.5 h / Ambient temperature
2: 1.) pyridine, DMF, copper powder, 4-dimethylaminopyridine / 1.) < -70 to 115 deg C; sealed tube, 2.) 8 h, 60 deg C; sealed tube was opened
3: methanolic HCl (2 percent) / 2 h / Ambient temperature
View Scheme
参考文献
Yamashita; Matsumotot; Kobayashi; Noguchi; Yasumoto; Ueda
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 9 p. 2287 - 2292
反应条件
1: 44 percent / silver oxide / butan-2-one / 2 h / Heating
2: 54 percent / 30percent NH4OH / ethanol; acetone / 2.5 h / Ambient temperature
View Scheme
参考文献
Yamashita; Takeda; Matsumoto; Unemi; Yasumoto
Journal of Medicinal Chemistry, 1989 , vol. 32, # 1 p. 136 - 139
反应条件
1: 44 percent / silver oxide / butan-2-one / 2 h / Heating
2: 54 percent / 30percent NH4OH / ethanol; acetone / 2.5 h / Ambient temperature
View Scheme
参考文献
Yamashita; Takeda; Matsumoto; Unemi; Yasumoto
Journal of Medicinal Chemistry, 1989 , vol. 32, # 1 p. 136 - 139
反应条件
1: 1.) pyridine, DMF, copper powder, 4-dimethylaminopyridine / 1.) < -70 to 115 deg C; sealed tube, 2.) 8 h, 60 deg C; sealed tube was opened
2: methanolic HCl (2 percent) / 2 h / Ambient temperature
View Scheme
参考文献
Yamashita; Matsumotot; Kobayashi; Noguchi; Yasumoto; Ueda
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 9 p. 2287 - 2292
反应条件
chloro-trimethyl-silane; sodium iodide in acetonitrile
2 h; Ambient temperature; Yield given;
参考文献
Yamashita; Matsumotot; Kobayashi; Noguchi; Yasumoto; Ueda
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 9 p. 2287 - 2292
