2-苯基-3-羟基-5-三氟甲基-2H-吡唑合成路线 （共 6 条）
反应条件
acetic acid T=10 - 80°C; 6.5 h;
参考文献
IHARA CHEMICAL INDUSTRY CO., LTD.
Patent: EP1767528 A1, 2007 ;
Location in patent: Page/Page column 11-12 ;
反应条件
hydrogenchloride; phenylhydrazine in methanol
参考文献
Sanofi
Patent: US5750550 A1, 1998 ;
反应条件
sodium hydroxide in ethanol 2 h; Heating;
参考文献
Kondrat'ev, P. N.; Skryabina, Z. E.; Saloutin, V. I.; Pashkevich, K. I.; Klyuev, N. A.; Aleksandrov, G. G.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990 , vol. 39, # 3.2 p. 561 - 565
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1990 , # 3 p. 640 - 645
反应条件
in methanol 6 h; Heating;
参考文献
Saloutin, V. I.; Fomin, A. N.; Pashkevich, K. I.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1985 , vol. 34, # 1 p. 135 - 141
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1985 , # 1 p. 144 - 151
反应条件
trichlorophosphate in DMF (N,N-dimethyl-formamide) T=0 - 20°C; 1 h; Heating / reflux;
参考文献
Takahashi, Satoru; Ueno, Ryohei; Yamaji, Yoshihiro; Fujinami, Makoto
Patent: US2005/256004 A1, 2005 ;
Location in patent: Page/Page column 28-29 ;
反应条件
trichlorophosphate T=80°C; 12 h;
参考文献
Gilbert, Adam M.; Bursavich, Matthew G.; Lombardi, Sabrina; Georgiadis, Katy E.; Reifenberg, Erica; Flannery, Carl R.; Morris, Elisabeth A.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1189 - 1192
