二薄荷基(1S,2S)-环丙烷-1,2-二羧酸酯合成路线 （共 3 条）
反应条件
potassium hydroxide in methanol; water T=60°C; 4 h;
参考文献
Pokorski, Jonathan K.; Myers, Michael C.; Appella, Daniel H.
Tetrahedron Letters, 2005 , vol. 46, # 6 p. 915 - 917
反应条件
1: 5 N aq. NaOH / propan-2-ol / 70 °C 2: SOCl2 / Ambient temperature 3: 1.) Zn(Cu), 2.) Pd(Ph3P)4 / 1.) benzene, N,N-dimethylacetamide, 60 deg C, 3 h, 2.) benzene, N,N-dimethylacetamide, RT, 1 h 4: 1 N aq. NaOH / ethanol / 24 h / 55 °C View Scheme
参考文献
Ornstein, Paul L.; Bleisch, Thomas J.; Arnold, M. Brian; Kennedy, Joseph H.; Wright, Rebecca A.; Johnson, Bryan G.; Tizzano, Joseph P.; Helton, David R.; Kallman, Mary Jeanne; Schoepp, Darryle D.; Herin, Marc
Journal of Medicinal Chemistry, 1998 , vol. 41, # 3 p. 358 - 378
反应条件
1: 5 N aq. NaOH / propan-2-ol / 70 °C 2: SOCl2 / Ambient temperature 3: 1.) Zn(Cu), 2.) Pd(Ph3P)4 / 1.) benzene, N,N-dimethylacetamide, 60 deg C, 3 h, 2.) benzene, N,N-dimethylacetamide, RT, 1 h View Scheme
参考文献
Ornstein, Paul L.; Bleisch, Thomas J.; Arnold, M. Brian; Kennedy, Joseph H.; Wright, Rebecca A.; Johnson, Bryan G.; Tizzano, Joseph P.; Helton, David R.; Kallman, Mary Jeanne; Schoepp, Darryle D.; Herin, Marc
Journal of Medicinal Chemistry, 1998 , vol. 41, # 3 p. 358 - 378
