1: CHCl3 / 3 h / Heating 2: 1.) 1N aq.NaOH / 1.) chloroform, 23 grad C, 3 min; 2). benzene, 23 grad C, 10 h. 3: NaBH4 / methanol / 0.17 h / -40 °C View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '19274129', constants.ctx, '0')">Jones Reagens</a> <br />T=23&deg;C;&nbsp;1.5&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>2: 89 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 4 h / 23 &deg;C<br />3: 99 percent / H₂ / Lindlar / tetrahydrofuran / 0.75 h / 23 &deg;C<br />4: 99 percent / potassium bromide / tetrahydrofuran; aq. acetic acid / 10 h / 0 &deg;C<br />5: 92 percent / Jones reagens / 1.5 h / 23 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 89 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 4 h / 23 &deg;C<br />2: 99 percent / H₂ / Lindlar / tetrahydrofuran / 0.75 h / 23 &deg;C<br />3: 99 percent / potassium bromide / tetrahydrofuran; aq. acetic acid / 10 h / 0 &deg;C<br />4: 92 percent / Jones reagens / 1.5 h / 23 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 99 percent / potassium bromide / tetrahydrofuran; aq. acetic acid / 10 h / 0 &deg;C<br />2: 92 percent / Jones reagens / 1.5 h / 23 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 7 steps<br /> </b>1: 76 percent / Jones reagent / 0 &deg;C<br />2: 1.) C₂H₅MgBr; 2.) CuBr / 1.) THF, 0 deg C; 2.) 0 deg C for 15 min, reflux for 8 h.<br />4: 89 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 4 h / 23 &deg;C<br />5: 99 percent / H₂ / Lindlar / tetrahydrofuran / 0.75 h / 23 &deg;C<br />6: 99 percent / potassium bromide / tetrahydrofuran; aq. acetic acid / 10 h / 0 &deg;C<br />7: 92 percent / Jones reagens / 1.5 h / 23 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 6 steps<br /> </b>1: 1.) C₂H₅MgBr; 2.) CuBr / 1.) THF, 0 deg C; 2.) 0 deg C for 15 min, reflux for 8 h.<br />3: 89 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 4 h / 23 &deg;C<br />4: 99 percent / H₂ / Lindlar / tetrahydrofuran / 0.75 h / 23 &deg;C<br />5: 99 percent / potassium bromide / tetrahydrofuran; aq. acetic acid / 10 h / 0 &deg;C<br />6: 92 percent / Jones reagens / 1.5 h / 23 &deg;C<br /> <br /> &nbsp;