3-(4-乙基苯基))-3-氧丙腈合成路线 （共 3 条）
反应条件
1: anhydrous cyanoacetic acid With n-butyllithium in tetrahydrofuran; hexane T=-78 - 0°C; 0.5 h; 2: 4-ethyl-benzoyl chloride in tetrahydrofuran; hexane T=-78 - 20°C; 2 h;
参考文献
INPHARMATICA LIMITED
Patent: WO2007/36730 A1, 2007 ;
Location in patent: Page/Page column 19-20 ;
WO 2007/036730 A1
反应条件
ZnF2; [Pd(η3-2-Me-C3H4)(μ-Cl)]2; copper(ll) bromide in N,N-dimethyl-formamide T=80°C; P=7600.51 Torr; 12 h;
参考文献
Park, Ahbyeol; Lee, Sunwoo
Organic Letters, 2012 , vol. 14, # 4 p. 1118 - 1121
反应条件
CuF2; bis-triphenylphosphine-palladium(II) chloride in acetonitrile T=80°C; 16 h;
参考文献
Pyo, Ayoung; Park, Ahbyeol; Jung, Hyunmin; Lee, Sunwoo
Synthesis (Germany), 2012 , vol. 44, # 18 p. 2885 - 2888
