1: 76 percent / acetic anhydride / 1 h / 140 °C 2: SnCl2*2H2O, 12N HCl / H2O / 1.) 0 deg C, 2 h, 2.) 25 deg C, 16 h 3: KOH / H2O; ethanol / 2 h / Heating 4: 85 percent / Na / ethanol / 3 h / Heating 5: 80 percent / Et4N(1+)Cl(1-), PhNEt2,POCl3 / acetonitrile / 4 h / 100 °C 6: 53 percent / Na / NH3 / 2.5 h / -75 °C 7: 11 percent / 810 - 850 °C / 0 Torr View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '969510', constants.ctx, '0')">isopentyl nitrite</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098214', constants.ctx, '0')">hydrogenchloride</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1718733', constants.ctx, '0')">ethanol</a> <br />&nbsp;1.) 0 deg C, 30 min, 2.) 25 deg C, 16 h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 6 steps<br /> </b>1: 86 percent / butan-1-ol / 4 h / Heating<br />2: H₂ / Raney Ni / dimethylformamide; aq. NH₃ / 2 h / 25 &deg;C / 2280 Torr<br />3: 80 percent / HCOOH / 3 h / Heating<br />4: 92 percent / aq. HCl / ethanol / 1.5 h / Heating<br />6: 80 percent / isoamyl nitrite / ethanol; HCl / 1.) 0 deg C, 30 min, 2.) 25 deg C, 16 h<br /> <br /> &nbsp;

<b>Multi-step reaction with 6 steps<br /> </b>1: 86 percent / butan-1-ol / 4 h / Heating<br />2: H₂ / Raney Ni / dimethylformamide; aq. NH₃ / 2 h / 25 &deg;C / 2280 Torr<br />3: 80 percent / HCOOH / 3 h / Heating<br />4: 92 percent / aq. HCl / ethanol / 1.5 h / Heating<br />6: 80 percent / isoamyl nitrite / ethanol; HCl / 1.) 0 deg C, 30 min, 2.) 25 deg C, 16 h<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>2: 80 percent / isoamyl nitrite / ethanol; HCl / 1.) 0 deg C, 30 min, 2.) 25 deg C, 16 h<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 80 percent / HCOOH / 3 h / Heating<br />2: 92 percent / aq. HCl / ethanol / 1.5 h / Heating<br />4: 80 percent / isoamyl nitrite / ethanol; HCl / 1.) 0 deg C, 30 min, 2.) 25 deg C, 16 h<br /> <br /> &nbsp;