2: 1) Na/Hg, 2) pyridine, HOAc / 1) MeOH, EtOAc, -35 deg C, 5 h, 2) 0 deg C, overnight View Scheme

<b>Multi-step reaction with 3 steps<br /> </b>1: 74 percent / H₂, NEt₃ / 5percent Pd/CaCO₃ / tetrahydrofuran<br />2: 58 percent / PBr₃, NEt₃ / diethyl ether / a) -30 deg C, 1 h, b) 0 deg C, 1 h<br />3: 80 percent / methanol / 72 h / Ambient temperature<br /> <br /> &nbsp;

&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098229', constants.ctx, '0')">methanol</a> <br />72&nbsp;h;&nbsp;&nbsp;Ambient temperature;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 58 percent / PBr₃, NEt₃ / diethyl ether / a) -30 deg C, 1 h, b) 0 deg C, 1 h<br />2: 80 percent / methanol / 72 h / Ambient temperature<br /> <br /> &nbsp;