3-溴-2,4-二甲氧基吡啶合成路线 （共 6 条）
反应条件
sodium hydroxide; hydrogen; palladium on activated charcoal in ethanol T=23°C; P=2052 Torr; 2 h;
参考文献
Gibson, Katharine J.; d'Alarcao, Marc; Leonard, Nelson J.
Journal of Organic Chemistry, 1985 , vol. 50, # 14 p. 2462 - 2468
反应条件
sodium methylate
T=130°C; 13 h;
参考文献
Gibson, Katharine J.; d'Alarcao, Marc; Leonard, Nelson J.
Journal of Organic Chemistry, 1985 , vol. 50, # 14 p. 2462 - 2468
反应条件
silver carbonate
T=20°C; 72 h; Inert atmosphere;
参考文献
Jones, Ian L.; Moore, Felicity K.; Chai, Christina L. L.
Organic Letters, 2009 , vol. 11, # 23 p. 5526 - 5529
反应条件
1: 70 percent / POBr3
2: 73 percent / CH3ONa / methanol / 1.25 h / 140 °C / under pressure in the sealed vessel
3: 61 percent / CH3ONa / 13 h / 130 °C
View Scheme
参考文献
Gibson, Katharine J.; d'Alarcao, Marc; Leonard, Nelson J.
Journal of Organic Chemistry, 1985 , vol. 50, # 14 p. 2462 - 2468
反应条件
1: 73 percent / CH3ONa / methanol / 1.25 h / 140 °C / under pressure in the sealed vessel
2: 61 percent / CH3ONa / 13 h / 130 °C
View Scheme
参考文献
Gibson, Katharine J.; d'Alarcao, Marc; Leonard, Nelson J.
Journal of Organic Chemistry, 1985 , vol. 50, # 14 p. 2462 - 2468
反应条件
sodium methylate
T=130°C; 13 h;
参考文献
Gibson, Katharine J.; d'Alarcao, Marc; Leonard, Nelson J.
Journal of Organic Chemistry, 1985 , vol. 50, # 14 p. 2462 - 2468
