(2S,4R)-4-[[(4-甲基苯基)磺酰基]氧基]-1,2-吡咯烷二甲酸 1-叔丁酯合成路线 （共 12 条）
反应条件
copper(I) bromide dimethylsulfide complex; ammonium chloride 1./ ether-THF, 4 gradC, 1 h. 2./ H2O, 0 gradC, two hours; other reagent, solvent; Product distributionMechanism;
参考文献
Tetrahedron Letters, , vol. 27, # 2 p. 151 - 154
反应条件
copper(I) bromide dimethylsulfide complex; ammonium chloride 1./ ether-THF, 4 gradC, 1 h. 2./ H2O, 0 gradC, two hours; other reagent, solvent; Product distributionMechanism;
参考文献
Thottathil, John K.; Moniot, Jerome L.
Tetrahedron Letters, 1986 , vol. 27, # 2 p. 151 - 154
反应条件
sodium hydroxide in diethyl ether; water
T=20°C;
参考文献
Boitrel, Bernard; Baveux-Chambenoit, Valerie
New Journal of Chemistry, 2003 , vol. 27, # 6 p. 942 - 947
反应条件
1: 85 percent / aq. NaOH / 2-methyl-propan-2-ol / 18 h
2: 66 percent / aq. NaOH / diethyl ether / 24 h
View Scheme
参考文献
Baldwin, Jack E.; Field, Robert A.; Lawrence, Christopher C.; Merritt, Kirsten D.; Schofield, Christopher J.
Tetrahedron Letters, 1993 , vol. 34, # 46 p. 7489 - 7492
反应条件
1: 1./KOH 2./Et3N
2: pyridine
3: H2, / Pd-C
View Scheme
参考文献
Thottathil, John K.; Moniot, Jerome L.
Tetrahedron Letters, 1986 , vol. 27, # 2 p. 151 - 154
反应条件
1: pyridine
2: H2, / Pd-C
View Scheme
参考文献
Thottathil, John K.; Moniot, Jerome L.
Tetrahedron Letters, 1986 , vol. 27, # 2 p. 151 - 154
反应条件
1: pyridine
2: H2, / Pd-C
View Scheme
参考文献
Thottathil, John K.; Moniot, Jerome L.
Tetrahedron Letters, 1986 , vol. 27, # 2 p. 151 - 154
反应条件
hydrogen; palladium on activated charcoal
参考文献
Thottathil, John K.; Moniot, Jerome L.
Tetrahedron Letters, 1986 , vol. 27, # 2 p. 151 - 154
反应条件
1: 90 percent / sodium borohydride / methanol / 3.5 h / 0 °C
2: 62 percent / aq. NaOH / diethyl ether / 24 h
3: 36 percent / lithium triethylborodeuteride / tetrahydrofuran / 24 h / Heating
4: trifluoroacetic acid / 0.5 h
5: TES buffer, iron(II)ammonium sulphate, 2-oxoglutarate, proline 4-hydroxylase / 4 h / 26 °C / incubation
6: 85 percent / aq. NaOH / 2-methyl-propan-2-ol / 18 h
7: 66 percent / aq. NaOH / diethyl ether / 24 h
View Scheme
参考文献
Baldwin, Jack E.; Field, Robert A.; Lawrence, Christopher C.; Merritt, Kirsten D.; Schofield, Christopher J.
Tetrahedron Letters, 1993 , vol. 34, # 46 p. 7489 - 7492
反应条件
1: 62 percent / aq. NaOH / diethyl ether / 24 h
2: 36 percent / lithium triethylborodeuteride / tetrahydrofuran / 24 h / Heating
3: trifluoroacetic acid / 0.5 h
4: TES buffer, iron(II)ammonium sulphate, 2-oxoglutarate, proline 4-hydroxylase / 4 h / 26 °C / incubation
5: 85 percent / aq. NaOH / 2-methyl-propan-2-ol / 18 h
6: 66 percent / aq. NaOH / diethyl ether / 24 h
View Scheme
参考文献
Baldwin, Jack E.; Field, Robert A.; Lawrence, Christopher C.; Merritt, Kirsten D.; Schofield, Christopher J.
Tetrahedron Letters, 1993 , vol. 34, # 46 p. 7489 - 7492
