(2S,4R)-4-[[(4-甲基苯基)磺酰基]氧基]-1,2-吡咯烷二甲酸 1-叔丁酯合成路线 （共 12 条）
反应条件
1: TES buffer, iron(II)ammonium sulphate, 2-oxoglutarate, proline 4-hydroxylase / 4 h / 26 °C / incubation
2: 85 percent / aq. NaOH / 2-methyl-propan-2-ol / 18 h
3: 66 percent / aq. NaOH / diethyl ether / 24 h
View Scheme
参考文献
Baldwin, Jack E.; Field, Robert A.; Lawrence, Christopher C.; Merritt, Kirsten D.; Schofield, Christopher J.
Tetrahedron Letters, 1993 , vol. 34, # 46 p. 7489 - 7492
反应条件
1: 36 percent / lithium triethylborodeuteride / tetrahydrofuran / 24 h / Heating
2: trifluoroacetic acid / 0.5 h
3: TES buffer, iron(II)ammonium sulphate, 2-oxoglutarate, proline 4-hydroxylase / 4 h / 26 °C / incubation
4: 85 percent / aq. NaOH / 2-methyl-propan-2-ol / 18 h
5: 66 percent / aq. NaOH / diethyl ether / 24 h
View Scheme
参考文献
Baldwin, Jack E.; Field, Robert A.; Lawrence, Christopher C.; Merritt, Kirsten D.; Schofield, Christopher J.
Tetrahedron Letters, 1993 , vol. 34, # 46 p. 7489 - 7492
