四氢-2-(2-碘乙氧基)-2H-吡喃合成路线 (共 3 条)
反应条件
1: (Z)-4-(4-chloro-1,2-diphenylbut-1-enyl)phenol With sodium hydride in tetrahydrofuran T=20°C; 1 h; 2: tetrahydro-2-(2-iodoethoxy)-2H-pyran in tetrahydrofuran 9 h; Heating / reflux; 3: With hydrogenchloride; water in ethanol T=20°C; Product distribution / selectivity;
参考文献
Sodervall, Marja; Eloranta, Maire; Kalapudas, Arja
Patent: US2008/207956 A1, 2008 ;
Location in patent: Page/Page column 4 ;
反应条件
hydrogenchloride; potassium carbonate
1.) DMF, 110 deg C, 2 h, 2.) MeOH, 20 deg C, 18 h; Yield given. Multistep reaction;
参考文献
Hay; Wilson; Moselen; Palmer; Denny
Journal of Medicinal Chemistry, 1994 , vol. 37, # 3 p. 381 - 391
反应条件
lithium amide; ammonia
Yield given;
参考文献
Bailey, William F.; Tao, Yong
Tetrahedron Letters, 1997 , vol. 38, # 35 p. 6157 - 6158