2'-脱氧-6-O-甲基-鸟苷合成路线 （共 25 条）
反应条件
in methanol
T=55°C; 36 h;
参考文献
Gao, Hetian; Fathi, Reza; Gaffney, Barbara L.; Goswami, Bhaswati; Kung, Pei-Pei; et al.
Journal of Organic Chemistry, 1992 , vol. 57, # 25 p. 6954 - 6959
反应条件
trifluoroacetic acid in dichloromethane
0.166667 h;
参考文献
Roelen, H. C. P. F.; Brugghe, H. F.; Elst, H. van den; Klein, J. C.; Marel, G. A. van der; Boom, J. H. van
Recueil des Travaux Chimiques des Pays-Bas, 1992 , vol. 111, p. 227 - 234
反应条件
ammonium hydroxide
T=50°C; 72 h;
参考文献
Gaffney; Jones
Tetrahedron Letters, 1982 , vol. 23, # 22 p. 2253 - 2256
反应条件
Dowex 1 x 2 (OH-) resin
T=20°C;
参考文献
Janeba, Zlatko; Lin, Xiaoyu; Robins, Morris J.
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 1-2 p. 137 - 147
反应条件
1: 1.) Me3N, 2.) 1,8-diazabicyclo<5.4.0>undecene, 3.) NaOH
2: KOH-methanol / 22 °C
View Scheme
参考文献
Liguori, Angelo; Napoli, Anna; Siciliano, Carlo; Sindona, Giovanni
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1994 , # 8 p. 1833 - 1838
反应条件
1: 87 percent / Et3N, 4-dimethylaminopyridine / CH2Cl2 / 2 h / Ambient temperature
2: CH2Cl2 / 0.17 h / 0 °C
3: 1.) DBU 2.) 1N NaOH / 0.17 h / 0 °C
4: 100 percent / NH4OH / 72 h / 50 °C
View Scheme
参考文献
Gaffney; Jones
Tetrahedron Letters, 1982 , vol. 23, # 22 p. 2253 - 2256
反应条件
in methanol; N,N-dimethyl-formamide
T=70°C; 1 h; Further byproducts given;
参考文献
Yamauchi, Kiyoshi; Nakagima, Toru; Kinoshita, Masayoshi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2787 - 2792
反应条件
in various solvent(s)
T=20°C; Methylation; pH=7.8; 24 h;
参考文献
Encell; Shuker; Foiles; Gold
Chemical Research in Toxicology, 1996 , vol. 9, # 3 p. 563 - 567
反应条件
in various solvent(s)
T=20°C; Methylation; pH=8.0; 24 h;
参考文献
Encell; Shuker; Foiles; Gold
Chemical Research in Toxicology, 1996 , vol. 9, # 3 p. 563 - 567
反应条件
1: 95 percent / pyridine; EtN(iPr)2 / 20 °C
2: Ph3P; I2; EtN(iPr)2 / toluene / 2 h / 80 °C
3: AcOH; H2O / dioxane / 20 °C
4: 407 mg / NH3 / methanol / 3 h / 70 °C
5: 52 percent / Dowex 1 x 2 (OH-) resin / 20 °C
View Scheme
参考文献
Janeba, Zlatko; Lin, Xiaoyu; Robins, Morris J.
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 1-2 p. 137 - 147
