2'-脱氧-6-O-甲基-鸟苷合成路线 （共 25 条）
反应条件
1: 48 percent / powdered KOH, tris<2-(2-methoxy-ethoxy)ethyl>amine / acetonitrile / 0.25 h
2: 76 percent / 0.1M NaOMe / methanol / 1 h
View Scheme
参考文献
Seela; Leonard
Helvetica Chimica Acta, 1996 , vol. 79, # 2 p. 477 - 487
反应条件
1: 48 percent / powdered KOH, tris<2-(2-methoxy-ethoxy)ethyl>amine / acetonitrile / 0.25 h
2: 76 percent / 0.1M NaOMe / methanol / 1 h
View Scheme
参考文献
Seela; Leonard
Helvetica Chimica Acta, 1996 , vol. 79, # 2 p. 477 - 487
反应条件
1: 407 mg / NH3 / methanol / 3 h / 70 °C
2: 52 percent / Dowex 1 x 2 (OH-) resin / 20 °C
View Scheme
参考文献
Janeba, Zlatko; Lin, Xiaoyu; Robins, Morris J.
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 1-2 p. 137 - 147
反应条件
1: Ph3P; I2; EtN(iPr)2 / toluene / 2 h / 80 °C
2: 813 mg / AcOH; H2O / dioxane / 3 h / 55 °C
3: 407 mg / NH3 / methanol / 3 h / 70 °C
4: 52 percent / Dowex 1 x 2 (OH-) resin / 20 °C
View Scheme
参考文献
Janeba, Zlatko; Lin, Xiaoyu; Robins, Morris J.
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 1-2 p. 137 - 147
反应条件
1: Ph3P; I2; EtN(iPr)2 / toluene / 2 h / 80 °C
2: AcOH; H2O / dioxane / 20 °C
3: 407 mg / NH3 / methanol / 3 h / 70 °C
4: 52 percent / Dowex 1 x 2 (OH-) resin / 20 °C
View Scheme
参考文献
Janeba, Zlatko; Lin, Xiaoyu; Robins, Morris J.
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 1-2 p. 137 - 147
反应条件
1: N-methylimidazole (NMI) / pyridine / 0.5 h / 20 °C
2: 81 percent / 4-(dimethylamino)pyridine (DMAP), triethylamine / CH2Cl2 / 16 h
3: 71 percent / N-methylpyrrolidine, 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / CH2Cl2 / 20 h / 20 °C
4: 85 percent / NH3 / methanol / 16 h / 0 - 5 °C
5: 54 percent / TFA / CH2Cl2 / 0.17 h
View Scheme
参考文献
Roelen, H. C. P. F.; Brugghe, H. F.; Elst, H. van den; Klein, J. C.; Marel, G. A. van der; Boom, J. H. van
Recueil des Travaux Chimiques des Pays-Bas, 1992 , vol. 111, p. 227 - 234
反应条件
1: conc. NH4OH / dioxane / 24 h / 50 °C
2: N-methylimidazole (NMI) / pyridine / 0.5 h / 20 °C
3: 81 percent / 4-(dimethylamino)pyridine (DMAP), triethylamine / CH2Cl2 / 16 h
4: 71 percent / N-methylpyrrolidine, 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / CH2Cl2 / 20 h / 20 °C
5: 85 percent / NH3 / methanol / 16 h / 0 - 5 °C
6: 54 percent / TFA / CH2Cl2 / 0.17 h
View Scheme
参考文献
Roelen, H. C. P. F.; Brugghe, H. F.; Elst, H. van den; Klein, J. C.; Marel, G. A. van der; Boom, J. H. van
Recueil des Travaux Chimiques des Pays-Bas, 1992 , vol. 111, p. 227 - 234
反应条件
1: 88 percent / pyridine / 1 h / 20 °C
2: conc. NH4OH / dioxane / 24 h / 50 °C
3: N-methylimidazole (NMI) / pyridine / 0.5 h / 20 °C
4: 81 percent / 4-(dimethylamino)pyridine (DMAP), triethylamine / CH2Cl2 / 16 h
5: 71 percent / N-methylpyrrolidine, 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / CH2Cl2 / 20 h / 20 °C
6: 85 percent / NH3 / methanol / 16 h / 0 - 5 °C
7: 54 percent / TFA / CH2Cl2 / 0.17 h
View Scheme
参考文献
Roelen, H. C. P. F.; Brugghe, H. F.; Elst, H. van den; Klein, J. C.; Marel, G. A. van der; Boom, J. H. van
Recueil des Travaux Chimiques des Pays-Bas, 1992 , vol. 111, p. 227 - 234
反应条件
1: 85 percent / NH3 / methanol / 16 h / 0 - 5 °C
2: 54 percent / TFA / CH2Cl2 / 0.17 h
View Scheme
参考文献
Roelen, H. C. P. F.; Brugghe, H. F.; Elst, H. van den; Klein, J. C.; Marel, G. A. van der; Boom, J. H. van
Recueil des Travaux Chimiques des Pays-Bas, 1992 , vol. 111, p. 227 - 234
反应条件
1: 81 percent / 4-(dimethylamino)pyridine (DMAP), triethylamine / CH2Cl2 / 16 h
2: 71 percent / N-methylpyrrolidine, 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / CH2Cl2 / 20 h / 20 °C
3: 85 percent / NH3 / methanol / 16 h / 0 - 5 °C
4: 54 percent / TFA / CH2Cl2 / 0.17 h
View Scheme
参考文献
Roelen, H. C. P. F.; Brugghe, H. F.; Elst, H. van den; Klein, J. C.; Marel, G. A. van der; Boom, J. H. van
Recueil des Travaux Chimiques des Pays-Bas, 1992 , vol. 111, p. 227 - 234
