2'-脱氧-6-O-甲基-鸟苷合成路线 （共 25 条）
反应条件
1: 71 percent / N-methylpyrrolidine, 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / CH2Cl2 / 20 h / 20 °C
2: 85 percent / NH3 / methanol / 16 h / 0 - 5 °C
3: 54 percent / TFA / CH2Cl2 / 0.17 h
View Scheme
参考文献
Roelen, H. C. P. F.; Brugghe, H. F.; Elst, H. van den; Klein, J. C.; Marel, G. A. van der; Boom, J. H. van
Recueil des Travaux Chimiques des Pays-Bas, 1992 , vol. 111, p. 227 - 234
反应条件
pyridine; trifluoroacetic anhydride
1. ice bath, 10 min, 2. methanol, 24 h; Yield given. Multistep reaction;
参考文献
Fathi; Goswami; Kung; Gaffney; Jones
Tetrahedron Letters, 1990 , vol. 31, # 3 p. 319 - 322
反应条件
potassium carbonate in methanol
T=20°C; Hydrolysis; Product distribution; Further Variations:Reagents;
参考文献
Xu, Yao-Zhong
Tetrahedron, 2000 , vol. 56, # 33 p. 6075 - 6081
反应条件
sodium hydroxide in water
T=20°C; Hydrolysis; Product distribution; Further Variations:Reagents;
参考文献
Xu, Yao-Zhong
Tetrahedron, 2000 , vol. 56, # 33 p. 6075 - 6081
反应条件
sodium hydroxide; phosphate buffer in methanol; water
T=37°C; various pH values; Product distribution;
参考文献
Golding, Bernard T.; Bleasdale, Christine; McGinnis, Joseph; Mueller, Susanna; Rees, Hue Thu; Rees, Nicholas H.; Farmer, Peter B.; Watson, William P.
Tetrahedron, 1997 , vol. 53, # 11 p. 4063 - 4082
