1.1: dichloromethane / 12 h / 40 - 50 °C 2.1: ethanol; sodium tetrahydroborate / 8 h / 15 - 60 °C / Inert atmosphere 2.2: 3 h / -10 - 0 °C View Scheme

1.1: dichloromethane / 12 h / 40 - 50 °C 2.1: ethanol; sodium tetrahydroborate / 8 h / 15 - 60 °C / Inert atmosphere 2.2: 3 h / -10 - 0 °C 3.1: triethylamine / N,N-dimethylaminopyridine 4.1: sodium hydrogencarbonate; water; sodium dihydrogen phosphate dihydrate; CAL-B enzyme / 40 - 45 °C / Enzymatic reaction 5.1: potassium carbonate; methanol / 25 - 35 °C View Scheme