1: 87 percent / 50 percent KF/Celite / acetonitrile / 6 h / 60 °C 2: 1) NaBH4; 2) 10 percent HCl / 1) DMF, 100 deg C, 20 min; 2) DMF, 120 deg C, 2.5 h 3: diethyl ether 4: 30 percent H2O2 / tetrahydrofuran / 3 h 5: 1.3 g / 1 h / 90 °C 6: H2 / 5 percent Pd/C / ethanol 7: Bu4NBr, 5 percent NaOH / CH2Cl2 / 12 h 8: 1) 10 percent KOH; 2) 10 percent HCl / methanol / 0.5 h / 60 °C 9: 2.60 g / polyphosphoric acid / 3.5 h / 45 °C View Scheme

1: H2 / 5 percent Pd/C / ethanol 2: Bu4NBr, 5 percent NaOH / CH2Cl2 / 12 h 3: 1) 10 percent KOH; 2) 10 percent HCl / methanol / 0.5 h / 60 °C 4: 2.60 g / polyphosphoric acid / 3.5 h / 45 °C View Scheme

1: 30 percent H2O2 / tetrahydrofuran / 3 h 2: 1.3 g / 1 h / 90 °C 3: H2 / 5 percent Pd/C / ethanol 4: Bu4NBr, 5 percent NaOH / CH2Cl2 / 12 h 5: 1) 10 percent KOH; 2) 10 percent HCl / methanol / 0.5 h / 60 °C 6: 2.60 g / polyphosphoric acid / 3.5 h / 45 °C View Scheme

1: m-chloroperbenzoic acid 2: 1.68 g / dimethylsulfoxide / 1.5 h / 170 °C 3: H2 / 5 percent Pd/C / ethanol 4: Bu4NBr, 5 percent NaOH / CH2Cl2 / 12 h 5: 1) 10 percent KOH; 2) 10 percent HCl / methanol / 0.5 h / 60 °C 6: 2.60 g / polyphosphoric acid / 3.5 h / 45 °C View Scheme

1: 1.68 g / dimethylsulfoxide / 1.5 h / 170 °C 2: H2 / 5 percent Pd/C / ethanol 3: Bu4NBr, 5 percent NaOH / CH2Cl2 / 12 h 4: 1) 10 percent KOH; 2) 10 percent HCl / methanol / 0.5 h / 60 °C 5: 2.60 g / polyphosphoric acid / 3.5 h / 45 °C View Scheme

PPA T=45°C; 3.5 h;

1: Bu4NBr, 5 percent NaOH / CH2Cl2 / 12 h 2: 1) 10 percent KOH; 2) 10 percent HCl / methanol / 0.5 h / 60 °C 3: 2.60 g / polyphosphoric acid / 3.5 h / 45 °C View Scheme