1: 62 percent / NaHCO3 / tetrahydrofuran; H2O / 24 h / Heating 2: 2 N aq. HCl / acetone; H2O / 24 h / 40 °C 3: 57 percent / benzene / 50 h / 30 - 40 °C 4: 82 percent / 2 N aq. Na2CO3 / dioxane / 5 h / Heating View Scheme

1: 62 percent / NaHCO3 / tetrahydrofuran; H2O / 24 h / Heating 2: 2 N aq. HCl / acetone; H2O / 24 h / 40 °C View Scheme

1: 62 percent / NaHCO3 / tetrahydrofuran; H2O / 24 h / Heating 2: 2 N aq. HCl / acetone; H2O / 24 h / 40 °C 3: 57 percent / benzene / 50 h / 30 - 40 °C View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '4948473', constants.ctx, '0')">magnesium</a> <br />&nbsp;1) THF, 2) THF, 2 h, reflux;&nbsp;&nbsp;Yield given. Multistep reaction;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 55 percent / TsOH / toluene / Heating<br />2: 1.) Mg / 1.) THF, 2.) reflux, 2 h<br /> <br /> &nbsp;