3-(苄氧基)-2,2-二甲基丙酸甲酯合成路线 （共 6 条）
反应条件
sodium hydride in tetrahydrofuran
T=20°C; 24 h;
参考文献
Rega, Miriam; Candal, Paloma; Jimenez, Carlos; Rodriguez, Jaime
European Journal of Organic Chemistry, 2007 , # 6 p. 934 - 942
反应条件
1: methyl 2,2-dimethyl-3-hydroxypropionate With sodium hydride in tetrahydrofuran
T=0°C; 0.333333 h;
2: benzyl bromide in tetrahydrofuran
参考文献
BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.
Patent: WO2005/90333 A1, 2005 ;
Location in patent: Page/Page column 138 ;
参考文献
JAPAN TOBACCO INC.
Patent: US2012/322837 A1, 2012 ;
Location in patent: Page/Page column 98 ;
US 20120322837 A1
反应条件
1: 88 percent / aq. KOH / ethanol / 1 h / 20 °C
2: 84 percent / tetrahydrofuran / 24 h
3: 89 percent / aq. HCl / tetrahydrofuran / 20 °C
View Scheme
参考文献
Iliev, Boyan; Linden, Anthony; Heimgartner, Heinz
Helvetica Chimica Acta, 2003 , vol. 86, # 9 p. 3215 - 3234
反应条件
lithium borohydride in tetrahydrofuran
参考文献
JAPAN TOBACCO INC.
Patent: US2012/322837 A1, 2012 ;
Location in patent: Page/Page column 98 ;
US 20120322837 A1
反应条件
1: lithium borohydride / tetrahydrofuran
2: triethylamine; pyridine-SO3 complex / dichloromethane; dimethyl sulfoxide
View Scheme
参考文献
JAPAN TOBACCO INC.
Patent: US2012/322837 A1, 2012 ;
US 20120322837 A1
