water; Pseudomonas lipase enzyme in tetrahydrofuran 0.05 M aq. phoshate buffer (pH 7.0), at pH 8.0 (0.1 N aq. NaOH solution); Yield given. Yields of byproduct given. Title compound not separated from byproducts;

water; Pseudomonas lipase enzyme in tetrahydrofuran 0.05 M aq. phoshate buffer (pH 7.0), at pH 8.0 (0.1 N aq. NaOH solution); Yield given. Yields of byproduct given. Title compound not separated from byproducts;

amano lipase from Pseudomonasfluorescens in tetrahydrofuran; aq. phosphate buffer; water Resolution of racemateEnzymatic reaction;

1: 79 percent / pyridine / 24 h / Ambient temperature 2: 1.) BF3*Et2O, AcOH, Ac2O, 2.) p-TsOH*H2O / 1.) reflux, 18.5 h, 2.) reflux, 20 h 3: 82.2 percent / K2CO3 / acetone; dimethylformamide / 27 h / Heating 4: K2CO3 / acetone; dimethylformamide / 5.5 h / Heating 5: LiOH*H2O / tetrahydrofuran; H2O / 6 h / Ambient temperature View Scheme

Multi-step reaction with 2 steps 1: BF3*OEt2 / acetic acid / 18 h / Heating2: p-toluenesulfonic acid / 18 h / Heating  

Multi-step reaction with 3 steps 1: BF3*OEt2 / acetic acid / 18 h / Heating2: p-toluenesulfonic acid / 18 h / Heating3: 97 percent / K2CO3 / dimethylsulfoxide / 18 h / Ambient temperature