lithium hydroxide in tetrahydrofuran; water 6 h; Ambient temperature;

1: 81.6 percent / K2CO3 / 18-crown-6 / acetonitrile / 22 h / Heating 2: 96.8 percent / K2CO3 / acetone; dimethylformamide / 5.5 h / Heating 3: 72 percent / LiOH*H2O / tetrahydrofuran; H2O / 6 h / Ambient temperature View Scheme

1: 73.4 percent / H2 / 10percent Pd/C / acetic acid / 41 h / Ambient temperature 2: 79 percent / pyridine / 24 h / Ambient temperature 3: 1.) BF3*Et2O, AcOH, Ac2O, 2.) p-TsOH*H2O / 1.) reflux, 18.5 h, 2.) reflux, 20 h 4: 82.2 percent / K2CO3 / acetone; dimethylformamide / 27 h / Heating 5: K2CO3 / acetone; dimethylformamide / 5.5 h / Heating 6: LiOH*H2O / tetrahydrofuran; H2O / 6 h / Ambient temperature View Scheme

1: 81.6 percent / K2CO3 / 18-crown-6 / acetonitrile / 22 h / Heating 2: 96.8 percent / K2CO3 / acetone; dimethylformamide / 5.5 h / Heating 3: 72 percent / LiOH*H2O / tetrahydrofuran; H2O / 6 h / Ambient temperature View Scheme

1: 86 percent / NaOEt / ethanol / 3 h / 50 °C 2: 85 percent / H2 / 10 percent Pd/C / acetic acid; tetrahydrofuran / 45 °C / 3361.5 Torr 3: BF3*OEt2 / acetic acid / 18 h / Heating 4: p-toluenesulfonic acid / 18 h / Heating 5: 97 percent / K2CO3 / dimethylsulfoxide / 18 h / Ambient temperature 6: 94 percent / tetrabutylammonium hydroxide / methanol / 3 h / Ambient temperature 7: Et3N / 2 h / 6 °C 8: 81 percent / K2CO3, tris(3,6-dioxa-heptyl)amine / toluene / 6 h / Heating 9: 99 percent / aq. NaOH / methanol / 1.25 h / Heating 10: 2 N HCl View Scheme

1: 96.8 percent / K2CO3 / acetone; dimethylformamide / 5.5 h / Heating 2: 72 percent / LiOH*H2O / tetrahydrofuran; H2O / 6 h / Ambient temperature View Scheme

1: 79 percent / pyridine / 24 h / Ambient temperature 2: 1.) BF3*Et2O, AcOH, Ac2O, 2.) p-TsOH*H2O / 1.) reflux, 18.5 h, 2.) reflux, 20 h 3: 82.2 percent / K2CO3 / acetone; dimethylformamide / 27 h / Heating 4: K2CO3 / acetone; dimethylformamide / 5.5 h / Heating 5: LiOH*H2O / tetrahydrofuran; H2O / 6 h / Ambient temperature View Scheme

1: 82.2 percent / K2CO3 / acetone; dimethylformamide / 27 h / Heating 2: K2CO3 / acetone; dimethylformamide / 5.5 h / Heating 3: LiOH*H2O / tetrahydrofuran; H2O / 6 h / Ambient temperature View Scheme

1: 96 percent / H2 / 5 percent Pt/C / toluene; tetrahydrofuran / 1551.4 Torr / Ambient temperature 2: 81 percent / K2CO3, tris(3,6-dioxa-heptyl)amine / toluene / 6 h / Heating 3: 99 percent / aq. NaOH / methanol / 1.25 h / Heating 4: 2 N HCl View Scheme

1: 80 percent / xylene / 18 h / 215 °C 2: 96 percent / H2 / 5 percent Pt/C / toluene; tetrahydrofuran / 1551.4 Torr / Ambient temperature 3: 81 percent / K2CO3, tris(3,6-dioxa-heptyl)amine / toluene / 6 h / Heating 4: 99 percent / aq. NaOH / methanol / 1.25 h / Heating 5: 2 N HCl View Scheme