2,6-二氯-5-氟烟酰乙酸乙酯合成路线 （共 28 条）
反应条件
1.1: Ac2O / 1 h / 140 °C 1.2: 90 percent / ethanol / 20 °C 2.1: K2CO3 / dioxane View Scheme
参考文献
Chu, Daniel T. W.; Fernandes, Prabhavathi B.; Claiborne, Akiyo K.; Gracey, Eugene H.; Pernet, Andre G.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2364 - 2369
反应条件
acetic anhydride 1.) 130 deg C, 1 h, 2.) CH2Cl2, RT, 0.5 h; Yield given. Multistep reaction;
参考文献
Chu, Daniel T. W.; Fernandes, Prabhavathi B.; Claiborne, Akiyo K.; Gracey, Eugene H.; Pernet, Andre G.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2364 - 2369
反应条件
1: Ac2O / 15 h / 130 °C 2: ethanol / 1 h / Ambient temperature View Scheme
参考文献
Bouzard, D.; Cesare, P. Di; Essiz, M.; Jacquet, J. P.; Ledoussal, B.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 3 p. 518 - 525
反应条件
1: 1.) Ac2O / 1.) 130 deg C, 1 h, 2.) CH2Cl2, RT, 0.5 h 2: 59.6 percent / NaH / tetrahydrofuran / 1 h / Heating 3: 63.7 percent / pyridine / 3 h / Ambient temperature View Scheme
参考文献
Chu, Daniel T. W.; Fernandes, Prabhavathi B.; Claiborne, Akiyo K.; Gracey, Eugene H.; Pernet, Andre G.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2364 - 2369
反应条件
1: 1.) Ac2O / 1.) 130 deg C, 1 h, 2.) CH2Cl2, RT, 0.5 h 2: 86.5 percent / NaH / tetrahydrofuran / 1 h / Heating 3: 81.4 percent / pyridine / 3 h / Ambient temperature View Scheme
参考文献
Chu, Daniel T. W.; Fernandes, Prabhavathi B.; Claiborne, Akiyo K.; Gracey, Eugene H.; Pernet, Andre G.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2364 - 2369
反应条件
1.1: Ac2O / 1 h / 140 °C 1.2: 90 percent / ethanol / 20 °C 2.1: K2CO3 / dioxane 3.1: 20percent aq. HCl / Heating View Scheme
参考文献
Karoli, Tomislav; Mamidyala, Sreeman K.; Zuegg, Johannes; Fry, Scott R.; Tee, Ernest H.L.; Bradford, Tanya A.; Madala, Praveen K.; Huang, Johnny X.; Ramu, Soumya; Butler, Mark S.; Cooper, Matthew A.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2428 - 2433
反应条件
hydrogenchloride; acetic anhydride; triethylamine Yield given. Multistep reaction;
参考文献
Domagala, John M.; Hagen, Susan E.; Joannides, Themis; Kiely, John S.; Laborde, Edgardo; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 7 p. 871 - 882
反应条件
1: 1.) Ac2O / 1.) 130 deg C, 1 h, 2.) CH2Cl2, RT, 0.5 h 2: 86.5 percent / NaH / tetrahydrofuran / 1 h / Heating View Scheme
参考文献
Vymed Corporation; SHETTY, B. Vithal
Patent: US2014/73631 A1, 2014 ;
