1: 1) (+)-(S)-N,S-dimethyl-S-phenylsulfoximine, n-BuLi, 2) 2-methyl-1-propanol / 1) THF, -80 deg C, 1 h, 2) reflux 2: 92 percent / 37percent aq. HCl / CH2Cl2; methanol / 5 h / Ambient temperature 3: 1) LDA, TMSCl, 2) Pd(OAc)2 / 1) THF, -80 deg C, 1 h, 2) CH3CN, r.t., 5 h 4: 1) HMDS, n-BuLi, 2) AcOH / 1) THF/HMPT, -80 deg C, 1 h, 2) -80 deg C View Scheme

<b>Multi-step reaction with 4 steps<br /> </b>1: CuCl, AcOH<br />2: (i) HgSO₄, aq. H₂SO₄, (ii) /BRN= 1237255/, KOH<br />3: PhCO₂H, Et₃N / xylene / 168 h / Heating<br />4: H₂ / Pd-C<br /> <br /> &nbsp;

<b>Multi-step reaction with 7 steps<br /> </b>1: LiAlH₄ <br />2: PBr₃ <br />3: liq. NH₃ <br />4: CuCl, AcOH<br />5: (i) HgSO₄, aq. H₂SO₄, (ii) /BRN= 1237255/, KOH<br />6: PhCO₂H, Et₃N / xylene / 168 h / Heating<br />7: H₂ / Pd-C<br /> <br /> &nbsp;