N-乙基-N-3-((3-二甲氨基-1-氧代-2-丙烯基)苯基)乙酰胺合成路线 （共 6 条）
反应条件
in acetonitrile T=180°C; 0.166667 h; microwave irradiation;
参考文献
CYCLACEL LIMITED
Patent: WO2005/12262 A1, 2005 ;
Location in patent: Page/Page column 45-46 ;
WO 2005/012262 A1
反应条件
1: 3-[3-(N',N'-dimethylamino)-1-oxo-2-propenyl]-N-acetanilide With sodium hydride in N,N-dimethyl-formamide; mineral oil T=20°C; 0.5 h; Inert atmosphere; 2: ethyl iodide in N,N-dimethyl-formamide; mineral oil T=0 - 20°C; 1 h; Inert atmosphere;
参考文献
WO2011/7180 A1, ;
Page/Page column 12 ;
反应条件
1.1: 80 °C 2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere 2.2: 1 h / 0 - 20 °C / Inert atmosphere View Scheme
反应条件
hydrogenchloride in water; butanone T=20 - 35°C; 1 - 2 h; Heating / reflux; Product distribution / selectivity;
参考文献
WO2005/70931 A1, ;
Page/Page column 11; 12-13 ;
反应条件
hydrogenchloride in ethanol; water
参考文献
Heterocycles, , vol. 80, # 2 p. 1359 - 1376
反应条件
hydrogenchloride in ethanol; water
参考文献
Radl, Stanislav; Blahovcova, Michaela; Tkadlecova, Marcela; Havlicek, Jaroslav
Heterocycles, 2010 , vol. 80, # 2 p. 1359 - 1376
