3-(4-溴苯基)-7-羟基-4H-苯并吡喃-4-酮合成路线 （共 6 条）
反应条件
piperidine in pyridine
T=120 - 130°C;
参考文献
Luk'yanchikov, M. S.; Khilya, V. P.; Kazakov, A. L.
Chemistry of Natural Compounds, 1985 , vol. 21, # 6 p. 740 - 743
Khimiya Prirodnykh Soedinenii, 1985 , vol. 21, # 6 p. 781 - 784
反应条件
1: 1-(2,4-dihydroxyphenyl)-2-(4'-bromophenyl)-ethanone With boron trifluoride diethyl etherate in N,N-dimethyl-formamide
T=55°C; Inert atmosphere;
2: N,N-dimethyl-formamide With methanesulfonyl chloride
T=55 - 80°C; 3 h; Inert atmosphere;
参考文献
Yeap, Guan-Yeow; Yam, Wan-Sinn; Dominiak, Paulina; Ito, Masato M.
Journal of Molecular Structure, 2010 , vol. 967, # 1-3 p. 25 - 33
反应条件
1: boron trifluoride diethyl etherate / 80 °C
2: 1.41 g / morpholine / propan-2-ol / 80 °C
View Scheme
参考文献
Gao, Guang-Yao; Li, Dian-Jun; Keung, Wing Ming
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 4069 - 4081
反应条件
1: boron trifluoride diethyl etherate / 80 °C
2: 1.41 g / morpholine / propan-2-ol / 80 °C
View Scheme
参考文献
Gao, Guang-Yao; Li, Dian-Jun; Keung, Wing Ming
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 4069 - 4081
反应条件
1: 90 percent / 1.) dry HCl, boron trifluoride etherate, 2.) water / 1.) halogen chloride passed 10h, 10h room temperature, 2.) 90 deg C, pH=1, 60 min
2: 93 percent / piperidine / pyridine / 10 h / 120 - 130 °C
View Scheme
参考文献
Luk'yanchikov, M. S.; Khilya, V. P.; Kazakov, A. L.
Chemistry of Natural Compounds, 1985 , vol. 21, # 6 p. 740 - 743
Khimiya Prirodnykh Soedinenii, 1985 , vol. 21, # 6 p. 781 - 784
反应条件
1: Et3N / 0.17 h / 0 °C
2: mixed anhydride of acetic and formic acid, Et3N / 0.25 h / 80 - 100 °C
View Scheme
参考文献
Pivovarenko, V. G.; Khilya, V. P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1992 , vol. 28, # 5 p. 497 - 502
Khimiya Geterotsiklicheskikh Soedinenii, Sbornik, 1992 , # 5 p. 595 - 600
