4-Iodophentermine合成路线 （共 4 条）
反应条件
sodium iodide; sodium nitrite in water
参考文献
University of Florida
Patent: US4894219 A1, 1990 ;
US 4894219 A
反应条件
1: 56 percent / conc. H2SO4, 70percent aq. HNO3 / 0.33 h
2: 3.87 g / NaOH, hydrazine, Raney nickel / ethanol / 0.33 h / 40 °C
3: 1.) 5percent aq. H2SO4, NaNO2, 2.) NaI / 1.) 30 min, 2.) 30 min
View Scheme
参考文献
Milecki, Jan; Baker, Stephen P.; Standifer, Kelly M.; Ishizu, Takashi; Chida, Yasuhiro; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 9 p. 1563 - 1566
反应条件
1: 3.87 g / NaOH, hydrazine, Raney nickel / ethanol / 0.33 h / 40 °C
2: 1.) 5percent aq. H2SO4, NaNO2, 2.) NaI / 1.) 30 min, 2.) 30 min
View Scheme
参考文献
Milecki, Jan; Baker, Stephen P.; Standifer, Kelly M.; Ishizu, Takashi; Chida, Yasuhiro; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 9 p. 1563 - 1566
反应条件
sulfuric acid; sodium iodide; sodium nitrite
1.) 30 min, 2.) 30 min; Multistep reaction;
参考文献
Milecki, Jan; Baker, Stephen P.; Standifer, Kelly M.; Ishizu, Takashi; Chida, Yasuhiro; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 9 p. 1563 - 1566
