5-氨基-1-(4-溴苯基)-4-氰基吡唑-3-羧酸乙酯合成路线 (共 2 条)
反应条件
sodium ethanolate in diethyl ether; ethanol 12 h; Ambient temperature;
参考文献
Bernard; Cocco; Maccioni; Plumitallo
Farmaco, Edizione Scientifica, 1985 , vol. 40, # 4 p. 259 - 271
反应条件
1: 1.) sodium nitrite, 6N HCl; 2.) sodium acetate / 1.) water; 2.) water, ethanol, 0 - 5 deg C, 3 h -> overnight 2: 85 percent / sodium ethoxide / ethanol; diethyl ether / 12 h / Ambient temperature View Scheme
参考文献
Farmaco, Edizione Scientifica, , vol. 40, # 4 p. 259 - 271