(4R,5R)-4,5-二氢-5-[4-(甲基磺酰基)苯基]-2-苯基-4-恶唑甲醇合成路线 （共 15 条）
反应条件
1: 95 percent Chromat. / (1,1,2,3,3,3-hexafluoropropyl)diethylamine (FPA) / CH2Cl2 / 2 h / 100 °C / 5171.5 Torr 2: 95 percent / 6 N HCl / 12 h / 100 - 105 °C 3: 84 percent / Et3N / methanol / 18 h / Ambient temperature View Scheme
参考文献
Schumacher; Clark; Murphy; Fischer
Journal of Organic Chemistry, 1990 , vol. 55, # 18 p. 5291 - 5294
反应条件
N-(1,1,2,3,3,3-hexafluoropropyl)-diethylamine in dichloromethane T=100°C; P=5171.5 Torr; 2 h;
参考文献
Journal of Organic Chemistry, , vol. 55, # 18 p. 5291 - 5294
反应条件
1-diethylamino-1,1-difluoro-2-chloro-2-fluoro-ethane in dichloromethane T=100°C; 5 h;
参考文献
Journal of Organic Chemistry, , vol. 55, # 18 p. 5291 - 5294
反应条件
potassium carbonate in glycerol
T=80 - 110°C; 10 h;
参考文献
KRKA, tovarna zdravil, d.d., Novo mesto
Patent: EP1785414 A1, 2007 ;
Location in patent: Page/Page column 5 ;
反应条件
triethylamine in 1,2-dichloro-ethane
T=0°C;
参考文献
INTERVET INTERNATIONAL B.V.; PAQUETTE, Leo, A.; TOWSON, James, C.
Patent: WO2010/14566 A2, 2010 ;
Location in patent: Page/Page column 51 ;
反应条件
potassium carbonate in glycerol
T=115°C; 18 h;
参考文献
Schumacher; Clark; Murphy; Fischer
Journal of Organic Chemistry, 1990 , vol. 55, # 18 p. 5291 - 5294
反应条件
in water; 1,2-dichloro-ethane
T=85°C; 6 h;
参考文献
INTERVET INTERNATIONAL B.V.; PAQUETTE, Leo, A.; TOWSON, James, C.
Patent: WO2010/14566 A2, 2010 ;
Location in patent: Page/Page column 50-51 ;
反应条件
sodium tetrahydroborate; calcium chloride in ethanol
T=25°C; 3 h;
参考文献
Clark; Fischer; Schumacher
Synthesis, 1991 , # 10 p. 891 - 894
反应条件
1: 94 percent / Et3N / ethanol; CH2Cl2 / 1 h / -5 - 0 °C
2: 95 percent / 35percent CH3CO3H in AcOH / CH2Cl2 / 1 h / Ambient temperature
3: 100 percent / SOCl2 / CHCl3 / 2 h / 45 °C
4: 90 percent / NaOEt / ethanol / 1 h / 25 °C
5: 85 percent / CaCl2, NaBH4 / ethanol / 3 h / 25 °C
View Scheme
参考文献
Clark; Fischer; Schumacher
Synthesis, 1991 , # 10 p. 891 - 894
反应条件
1: 95 percent / 35percent CH3CO3H in AcOH / CH2Cl2 / 1 h / Ambient temperature
2: 100 percent / SOCl2 / CHCl3 / 2 h / 45 °C
3: 90 percent / NaOEt / ethanol / 1 h / 25 °C
4: 85 percent / CaCl2, NaBH4 / ethanol / 3 h / 25 °C
View Scheme
参考文献
Clark; Fischer; Schumacher
Synthesis, 1991 , # 10 p. 891 - 894
