(4R,5R)-4,5-二氢-5-[4-(甲基磺酰基)苯基]-2-苯基-4-恶唑甲醇合成路线 （共 15 条）
反应条件
1: 100 percent / SOCl2 / CHCl3 / 2 h / 45 °C
2: 90 percent / NaOEt / ethanol / 1 h / 25 °C
3: 85 percent / CaCl2, NaBH4 / ethanol / 3 h / 25 °C
View Scheme
参考文献
Clark; Fischer; Schumacher
Synthesis, 1991 , # 10 p. 891 - 894
反应条件
1: 37 percent / HCl / 5 h / 50 °C
2: 94 percent / Et3N / ethanol; CH2Cl2 / 1 h / -5 - 0 °C
3: 95 percent / 35percent CH3CO3H in AcOH / CH2Cl2 / 1 h / Ambient temperature
4: 100 percent / SOCl2 / CHCl3 / 2 h / 45 °C
5: 90 percent / NaOEt / ethanol / 1 h / 25 °C
6: 85 percent / CaCl2, NaBH4 / ethanol / 3 h / 25 °C
View Scheme
参考文献
Clark; Fischer; Schumacher
Synthesis, 1991 , # 10 p. 891 - 894
反应条件
1: 90 percent / NaOEt / ethanol / 1 h / 25 °C
2: 85 percent / CaCl2, NaBH4 / ethanol / 3 h / 25 °C
View Scheme
参考文献
Clark; Fischer; Schumacher
Synthesis, 1991 , # 10 p. 891 - 894
反应条件
1: 94 percent / Et3N / ethanol; CH2Cl2 / 1 h / -5 - 0 °C
2: 95 percent / 35percent CH3CO3H in AcOH / CH2Cl2 / 1 h / Ambient temperature
3: 100 percent / SOCl2 / CHCl3 / 2 h / 45 °C
4: 90 percent / NaOEt / ethanol / 1 h / 25 °C
5: 85 percent / CaCl2, NaBH4 / ethanol / 3 h / 25 °C
View Scheme
参考文献
Clark; Fischer; Schumacher
Synthesis, 1991 , # 10 p. 891 - 894
反应条件
peracetic acid; potassium carbonate
1.) ethylene glycol, glycerol, 105 deg C, 18 h, 2.) AcOH, 20-25 deg C , 1 h; Yield given. Multistep reaction;
参考文献
Schumacher; Clark; Murphy; Fischer
Journal of Organic Chemistry, 1990 , vol. 55, # 18 p. 5291 - 5294
