N-苄基-4-苯氨基哌啶-4-氰基合成路线 （共 22 条）
反应条件
1: aq. HCl / 1 h / Heating 2: 71 percent / aq. acetic acid View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 13 p. 4207 - 4209
反应条件
1: 100 percent / CH2Cl2 / 0.5 h / 20 - 30 °C 2: aq. HCl / 1 h / Heating View Scheme
参考文献
Feldman; Brackeen
Journal of Organic Chemistry, 1990 , vol. 55, # 13 p. 4207 - 4209
反应条件
1: 90percent H2SO4 / 20 h 2: AcOH / toluene / 20 h / Heating 3: H2, conc. aq. HCl / 5percent Pd/C / methanol / 96 h / 2327.2 Torr 4: Na2CO3 / H2O; dioxane / 20 h / Ambient temperature 5: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 3 h 6: Na2CO3 / methanol; H2O / 3 h / Heating View Scheme
参考文献
Mavunkel, Babu J.; Lu, Zhijian; Goehring, R. Richard; Lu, Songfeng; Chakravarty, Sarvajit; Perumattam, John; Novotny, Elizabeth A.; Connolly, Maureen; Valentine, Heather; Kyle, Donald J.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 16 p. 3169 - 3173
反应条件
1: 77 percent / H2SO4 / 16 h / 20 °C 2: 76 percent / KOH / ethane-1,2-diol / 16 h / 190 °C View Scheme
参考文献
Colapret; Diamantidis; Spencer; Spaulding; Rudo
Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 968 - 974
反应条件
1.1: 77 percent / H2SO4 / 16 h / 20 °C 2.1: 76 percent / KOH / ethane-1,2-diol / 16 h / 190 °C 3.1: NaH / dimethylformamide 3.2: 42 percent / dimethylformamide / 48 h / 20 °C 4.1: 23 percent / 6 h / Heating View Scheme
参考文献
Henriksen, Gjermund; Platzer, Stefan; Marton, Janos; Hauser, Andrea; Berthele, Achim; Schwaiger, Markus; Marinelli, Luciana; Lavecchia, Antonio; Novellino, Ettore; Wester, Hans-Juergen
Journal of Medicinal Chemistry, 2005 , vol. 48, # 24 p. 7720 - 7732
反应条件
1.1: 77 percent / H2SO4 / 16 h / 20 °C 2.1: 76 percent / KOH / ethane-1,2-diol / 16 h / 190 °C 3.1: NaH / dimethylformamide 3.2: 42 percent / dimethylformamide / 48 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 24 p. 7720 - 7732
反应条件
1.1: 77 percent / H2SO4 / 16 h / 20 °C 2.1: 76 percent / KOH / ethane-1,2-diol / 16 h / 190 °C 3.1: NaH / dimethylformamide 3.2: 42 percent / dimethylformamide / 48 h / 20 °C 4.1: 23 percent / 6 h / Heating 5.1: 52 percent / H2 / Pd/C / ethanol / 24 h / 20 °C View Scheme
参考文献
Henriksen, Gjermund; Platzer, Stefan; Marton, Janos; Hauser, Andrea; Berthele, Achim; Schwaiger, Markus; Marinelli, Luciana; Lavecchia, Antonio; Novellino, Ettore; Wester, Hans-Juergen
Journal of Medicinal Chemistry, 2005 , vol. 48, # 24 p. 7720 - 7732
反应条件
sulfuric acid 48 h; Ambient temperature;
参考文献
Taber, Douglass F.; Rahimizadeh, Mohammad
Journal of Organic Chemistry, 1992 , vol. 57, # 14 p. 4037 - 4038
反应条件
1: 100 percent / CH2Cl2 / 0.5 h / 20 - 30 °C
2: 60 percent / aq. HCl / 1 h / Heating
3: 82 percent / aq. sodium hydroxide / 18.5 h / 225 °C
View Scheme
参考文献
Feldman; Brackeen
Journal of Organic Chemistry, 1990 , vol. 55, # 13 p. 4207 - 4209
反应条件
1: H2SO4
2: conc. HCl / Heating
3: 80 percent / toluene / 240 h / Heating
4: 95 percent / LiAlH4 / tetrahydrofuran; CH2Cl2 / Ambient temperature
View Scheme
参考文献
Colapret; Diamantidis; Spencer; Spaulding; Rudo
Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 968 - 974
