1-[(2,2-二乙氧基乙基)硫代]-3-甲氧基-苯合成路线 （共 12 条）
反应条件
1: 3-methoxy-benzenethiol With potassium carbonate in acetonitrile
T=20°C;
2: 2-bromoacetaldehyde diethyl acetal in acetonitrile
15 h;
参考文献
N.V. Organon
Patent: US2007/112019 A1, 2007 ;
Location in patent: Page/Page column 11/1 ;
反应条件
potassium carbonate in acetone
T=20°C; 12 h;
参考文献
Industry-University Cooperation Foundation Sogang University
Patent: US2010/261727 A1, 2010 ;
Location in patent: Page/Page column 17 ;
参考文献
He, John Xiaoqiang; Honigschmidt, Nicholas Allan; Kohn, Todd Jonathan; Rocco, Vincent Patrick; Spinazze, Patrick Gianpietro; Takeuchi, Kumiko
Patent: US2003/232833 A1, 2003 ;
Location in patent: Page 16 ;
参考文献
Merck and Co., Inc.
Patent: US4668697 A1, 1987 ;
反应条件
1: With methanesulfonic acid; Celite in hexane
1 h; Heating / reflux;
2:
3: With triethylamine
T=20°C;
参考文献
PFIZER INC.
Patent: WO2003/106462 A1, 2003 ;
Location in patent: Page 34 ;
反应条件
boron trifluoride diethyl etherate in dichloromethane
T=20°C; Inert atmosphere;
参考文献
Industry-University Cooperation Foundation Sogang University
Patent: US2010/261727 A1, 2010 ;
Location in patent: Page/Page column 17 ;
反应条件
methanesulfonic acid; boron trifluoride-diethyl ether complex; sodium hydrogencarbonate; potassium carbonate; triethylamine in hexane; dichloromethane; acetone
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US2004/9965 A1, 2004 ;
参考文献
Merck and Co., Inc.
Patent: US4668697 A1, 1987 ;
反应条件
Yield given. Multistep reaction. Title compound not separated from byproducts;
参考文献
Graham, Samuel L.; Shepard, Kenneth L.; Anderson, Paul S.; Baldwin, John J.; Best, Darryl B.; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 12 p. 2548 - 2554
反应条件
2: 29.7 g / pyridine hydrochloride / 2.5 h / 190 - 200 °C
View Scheme
参考文献
Graham, Samuel L.; Shepard, Kenneth L.; Anderson, Paul S.; Baldwin, John J.; Best, Darryl B.; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 12 p. 2548 - 2554
