2-苯基-1H-吲哚-5-甲腈合成路线 （共 19 条）
反应条件
1: |Acidic conditions
2: palladium dichloride; silver(I) acetate; sulfuric acid / N,N-dimethyl-formamide; acetonitrile / 0.67 h / 100 °C / |Sealed tube; |Microwave irradiation
View Scheme
参考文献
Miao, Tao; Li, Pinhua; Wang, Guan-Wu; Wang, Lei
Chemistry - An Asian Journal, 2013 , vol. 8, # 12 p. 3185 - 3190
反应条件
1: methanol / 10 h / Heating
2: polyphosphoric acid / 3 h / 120 °C
3: quinoline / 1 h / 230 °C
View Scheme
参考文献
Iwanowicz, Edwin J.; Lau, Wan F.; Lin, James; Roberts, Daniel G. M.; Seiler, Steven M.
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 12 p. 1339 - 1344
反应条件
1: methanol / 10 h / Heating
2: polyphosphoric acid / 3 h / 120 °C
3: quinoline / 1 h / 230 °C
View Scheme
参考文献
Iwanowicz, Edwin J.; Lau, Wan F.; Lin, James; Roberts, Daniel G. M.; Seiler, Steven M.
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 12 p. 1339 - 1344
反应条件
1: polyphosphoric acid / 3 h / 120 °C
2: quinoline / 1 h / 230 °C
View Scheme
参考文献
Iwanowicz, Edwin J.; Lau, Wan F.; Lin, James; Roberts, Daniel G. M.; Seiler, Steven M.
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 12 p. 1339 - 1344
反应条件
in quinoline
T=230°C; 1 h;
参考文献
Iwanowicz, Edwin J.; Lau, Wan F.; Lin, James; Roberts, Daniel G. M.; Seiler, Steven M.
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 12 p. 1339 - 1344
反应条件
1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere
2: potassium carbonate; L-proline; copper(I) bromide / dimethyl sulfoxide / 3 h / 100 °C / Inert atmosphere
View Scheme
参考文献
Ponpandian, Thanasekaran; Muthusubramanian, Shanmugam
Tetrahedron Letters, 2012 , vol. 53, # 32 p. 4248 - 4252
反应条件
1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 72 h / 20 °C / |Inert atmosphere
2: triethylamine / tetrahydrofuran / 16 h / 20 °C / |Inert atmosphere
3: caesium carbonate / toluene / 150 °C / |Sealed tube
View Scheme
参考文献
Herrero, Maria Teresa; De Sarralde, Jokin Diaz; Sanmartin, Raul; Bravo, Laura; Dominguez, Esther
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 16 p. 3054 - 3064
反应条件
1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 72 h / 20 °C / |Inert atmosphere
2: triethylamine / tetrahydrofuran / 16 h / 20 °C / |Inert atmosphere
3: caesium carbonate / toluene / 150 °C / |Sealed tube
View Scheme
参考文献
Herrero, Maria Teresa; De Sarralde, Jokin Diaz; Sanmartin, Raul; Bravo, Laura; Dominguez, Esther
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 16 p. 3054 - 3064
反应条件
1: toluene-4-sulfonic acid / toluene / |Molecular sieve; |Inert atmosphere; |Dean-Stark; |Reflux
2: palladium diacetate; triphenylphosphine; silver carbonate / 1,4-dioxane / 24 h / 120 °C / |Sealed tube
View Scheme
参考文献
Mahajan, Jyoti P.; Suryawanshi, Yogeshwar R.; Mhaske, Santosh B.
Organic Letters, 2012 , vol. 14, # 22 p. 5804 - 5807
