3-氨基-8-苄基-8-氮杂双环[3.2.1]辛烷合成路线 （共 4 条）
反应条件
sodium in pentan-1-ol
4 h; Heating / reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/54974 A2, 2004 ;
Location in patent: Page 55 ;
WO 2004/054974 A2
反应条件
1: With triphenylphosphine in tetrahydrofuran; water
Heating / reflux;
2: With hydrogenchloride in water; ethyl acetate
3: With sodium hydroxide in water; ethyl acetate
pH=14;
参考文献
MORPHOCHEM AKTIENGESELLSCHAFT FUeR KOMBINATORISCHE CHEMIE
Patent: WO2006/21448 A1, 2006 ;
Location in patent: Page/Page column 41-42 ;
反应条件
1: hydroxylamine hydrochloride; sodium carbonate / methanol / 5 h / 0 - 20 °C
2: platinum(IV) oxide; hydrogen / ethanol / 16 h / 2585.81 Torr
View Scheme
参考文献
Nguyen, Thuy; Sakasegawa, Yuji; Doh-Ura, Katsumi; Go, Mei-Lin
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 2917 - 2929
反应条件
1: triethylamine / tetrahydrofuran / 70 °C
2: hydroxylamine hydrochloride; sodium carbonate / methanol / 5 h / 0 - 20 °C
3: platinum(IV) oxide; hydrogen / ethanol / 16 h / 2585.81 Torr
View Scheme
参考文献
Nguyen, Thuy; Sakasegawa, Yuji; Doh-Ura, Katsumi; Go, Mei-Lin
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 2917 - 2929
