1: 2.) Ag2CO3 / 1.) CHCl3, iso-PrOH-DMF, 50 deg C, 2 h, 2.) reflux, 1 h 2: 81 mg / hydrogen / 10 percent Pd-C / methanol / 8 h / Ambient temperature 3: 59 mg / pyridine / 10 h / Ambient temperature View Scheme

1: 1M Na2CO3 2: CHCl3; dimethylformamide; propan-2-ol; H2O / 12 h / 50 °C 3: H2 / Pd/C / ethanol / 5 h / 50 °C 4: Et3N / CHCl3 View Scheme