5-(2-十二烷基苯基)-4,6-二硫杂壬烷二羧酸合成路线 （共 5 条）
反应条件
boron trifluoride diethyl etherate in dichloromethane
T=0°C; 0.166667 h;
参考文献
Perchonock; Uzinskas; McCarthy; Erhard; Gleason; Wasserman; Muccitelli; DeVan; Tucker; Vickery
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1442 - 1452
反应条件
1: 85 percent / (Ph3P)3PdCl2, CuI, Et3N / 15 h / Heating
2: 96 percent / H2 / 10percent Pd/C / ethyl acetate / 1.25 h / 2068.6 Torr
3: 89 percent / BF3*Et2O / CH2Cl2 / 0.25 h
View Scheme
参考文献
Perchonock; Uzinskas; McCarthy; Erhard; Gleason; Wasserman; Muccitelli; DeVan; Tucker; Vickery
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1442 - 1452
反应条件
1: 96 percent / H2 / 10percent Pd/C / ethyl acetate / 1.25 h / 2068.6 Torr
2: 89 percent / BF3*Et2O / CH2Cl2 / 0.25 h
View Scheme
参考文献
Perchonock; Uzinskas; McCarthy; Erhard; Gleason; Wasserman; Muccitelli; DeVan; Tucker; Vickery
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1442 - 1452
反应条件
1: 85 percent / (Ph3P)3PdCl2, CuI, Et3N / 15 h / Heating
2: 96 percent / H2 / 10percent Pd/C / ethyl acetate / 1.25 h / 2068.6 Torr
3: 89 percent / BF3*Et2O / CH2Cl2 / 0.25 h
View Scheme
参考文献
Perchonock; Uzinskas; McCarthy; Erhard; Gleason; Wasserman; Muccitelli; DeVan; Tucker; Vickery
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1442 - 1452
反应条件
1: 1.) NaBH4, 2.) aq. HCl / 1.) MeOH, 0 deg C, 30 min, 2.) acetone, RT, 18 h
2: 89 percent / BF3*Et2O / CH2Cl2 / 0.17 h / 0 °C
View Scheme
参考文献
Perchonock; McCarthy; Erhard; Gleason; Wasserman; Muccitelli; DeVan; Tucker; Vickery; Kirchner
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1145 - 1147
