5-(2-(8-苯基辛基)苯基)-4,6-二硫杂壬烷二羧酸合成路线 （共 12 条）
反应条件
boron trifluoride diethyl etherate in dichloromethane
T=0°C; 0.166667 h;
参考文献
Perchonock; McCarthy; Erhard; Gleason; Wasserman; Muccitelli; DeVan; Tucker; Vickery; Kirchner
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1145 - 1147
反应条件
1: 1.) n-BuLi, HMPA / 1.) THF, hexane, 20 min, 2.) THF, hexane, RT, 17 h
2: (Ph3P)3PdCl2, CuI, Et3N / 0.25 h
3: H2 / 10percent Pd/C / ethyl acetate / 1.25 h / 40 Torr
4: BF3*Et2O / CH2Cl2 / 0.25 h
View Scheme
参考文献
Perchonock; Uzinskas; McCarthy; Erhard; Gleason; Wasserman; Muccitelli; DeVan; Tucker; Vickery
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1442 - 1452
反应条件
1: (Ph3P)3PdCl2, CuI, Et3N / 0.25 h
2: H2 / 10percent Pd/C / ethyl acetate / 1.25 h / 40 Torr
3: BF3*Et2O / CH2Cl2 / 0.25 h
View Scheme
参考文献
Perchonock; Uzinskas; McCarthy; Erhard; Gleason; Wasserman; Muccitelli; DeVan; Tucker; Vickery
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1442 - 1452
反应条件
1: H2 / 10percent Pd/C / ethyl acetate / 1.25 h / 40 Torr
2: BF3*Et2O / CH2Cl2 / 0.25 h
View Scheme
参考文献
Perchonock; Uzinskas; McCarthy; Erhard; Gleason; Wasserman; Muccitelli; DeVan; Tucker; Vickery
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1442 - 1452
反应条件
1: (Ph3P)3PdCl2, CuI, Et3N / 0.25 h
2: H2 / 10percent Pd/C / ethyl acetate / 1.25 h / 40 Torr
3: BF3*Et2O / CH2Cl2 / 0.25 h
View Scheme
参考文献
Perchonock; Uzinskas; McCarthy; Erhard; Gleason; Wasserman; Muccitelli; DeVan; Tucker; Vickery
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1442 - 1452
反应条件
1: 95 percent / pyridine; H2O / 18 h / 4 °C
2: 1.) n-BuLi, HMPA / 1.) THF, hexane, 20 min, 2.) THF, hexane, RT, 17 h
3: (Ph3P)3PdCl2, CuI, Et3N / 0.25 h
4: H2 / 10percent Pd/C / ethyl acetate / 1.25 h / 40 Torr
5: BF3*Et2O / CH2Cl2 / 0.25 h
View Scheme
参考文献
Perchonock; Uzinskas; McCarthy; Erhard; Gleason; Wasserman; Muccitelli; DeVan; Tucker; Vickery
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1442 - 1452
反应条件
1: 1.) n-BuLi, HMPA / 1.) THF, hexane, 20 min, 2.) THF, hexane, RT, 17 h
2: (Ph3P)3PdCl2, CuI, Et3N / 0.25 h
3: H2 / 10percent Pd/C / ethyl acetate / 1.25 h / 40 Torr
4: BF3*Et2O / CH2Cl2 / 0.25 h
View Scheme
参考文献
Perchonock; Uzinskas; McCarthy; Erhard; Gleason; Wasserman; Muccitelli; DeVan; Tucker; Vickery
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1442 - 1452
反应条件
1: HMPA / tetrahydrofuran / 18 h / Ambient temperature
2: 69 percent / (Ph3P)2PdCl2, CuI, triethylamine
3: 98 percent / H2 / Pd/C
4: 89 percent / BF3*Et2O / CH2Cl2 / 0.17 h / 0 °C
View Scheme
参考文献
Perchonock; McCarthy; Erhard; Gleason; Wasserman; Muccitelli; DeVan; Tucker; Vickery; Kirchner
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1145 - 1147
反应条件
1: 1.) Mg / 1.) THF, 2.) THF, RT, 20 h
2: 18 h / Heating
3: 1.) NaBH4, 2.) 3 N HCl / 1.) MeOH, 15 min, 2.) acetone, RT, 19 h
4: BF3*Et2O / CH2Cl2 / 0.25 h
View Scheme
参考文献
Perchonock; Uzinskas; McCarthy; Erhard; Gleason; Wasserman; Muccitelli; DeVan; Tucker; Vickery
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1442 - 1452
反应条件
1: 94 percent / Ph3P, CBr4 / CH2Cl2 / 1 h
2: 1.) Mg / 1.) THF, 2.) THF, RT, 20 h
3: 18 h / Heating
4: 1.) NaBH4, 2.) 3 N HCl / 1.) MeOH, 15 min, 2.) acetone, RT, 19 h
5: BF3*Et2O / CH2Cl2 / 0.25 h
View Scheme
参考文献
Perchonock; Uzinskas; McCarthy; Erhard; Gleason; Wasserman; Muccitelli; DeVan; Tucker; Vickery
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1442 - 1452
