2'-脱氧-8-(苯基甲氧基)-鸟苷合成路线 （共 8 条）
反应条件
hydrogenchloride in methanol T=10°C; debenzylation; 1 h;
参考文献
Nampalli, Satyam; Kumar, Shiv
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1677 - 1679
反应条件
(HNBu3)2P2O7; triethyl phosphite; trichlorophosphate in N,N-dimethyl-formamide Substitution;
参考文献
Nampalli, Satyam; Livshin, Inna; Kumar, Shiv
Nucleosides and Nucleotides, 1999 , vol. 18, # 4-5 p. 697 - 699
反应条件
1: benzyl alcohol With sodium
T=20°C; Metallation; 3 h;
2: 8-bromo-dG in dimethyl sulfoxide
T=65°C; Substitution; 16 h;
参考文献
Nampalli, Satyam; Kumar, Shiv
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1677 - 1679
反应条件
sodium; sodium hydrogencarbonate; benzyl alcohol in water; dimethyl sulfoxide; acetone
参考文献
University of Washington
Patent: US6132776 A1, 2000 ;
反应条件
sodium; benzyl alcohol
T=65°C; Substitution; 16 h;
参考文献
Nampalli, Satyam; Livshin, Inna; Kumar, Shiv
Nucleosides and Nucleotides, 1999 , vol. 18, # 4-5 p. 697 - 699
反应条件
sodium
T=65°C; Substitution; 16 h;
参考文献
Nampalli, Satyam; Livshin, Inna; Kumar, Shiv
Nucleosides and Nucleotides, 1999 , vol. 18, # 4-5 p. 697 - 699
反应条件
in dimethyl sulfoxide; benzyl alcohol
T=65°C; 24 h; Yield given;
参考文献
Varaprasad, Chamakura V.; Bulychev, Nickolai; Grollman, Arthur P.; Johnson, Francis
Tetrahedron Letters, 1996 , vol. 37, # 1 p. 9 - 12
反应条件
1.1: bromine / water
2.1: sodium
2.2: 60 - 65 °C / Inert atmosphere
View Scheme
参考文献
Kannan, Arunkumar; Burrows, Cynthia J.
Journal of Organic Chemistry, 2011 , vol. 76, # 2 p. 720 - 723
