1-氯-2,4-二硝基苯合成路线 （共 755 条）
反应条件
1: diluted alcohol View Scheme
参考文献
Allen
Journal of the American Chemical Society, 1930 , vol. 52, p. 2956
Organic Syntheses, 1943 , vol. Coll. Vol. II, p. 228
反应条件
1: 50 percent / sodium acetate / ethanol / 1 h / Heating 2: 85 percent / tin dichloride, conc. HCl / dimethylformamide View Scheme
参考文献
Stankyavichyus, A. P.; Terent'ev, P. B.; Bolotin, V. A.; Lashin, V. V.; Rakhimi, I. M.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1988 , p. 403 - 409
Khimiya Geterotsiklicheskikh Soedinenii, 1988 , vol. 24, # 4 p. 491 - 498
反应条件
1: diluted alcohol View Scheme
参考文献
Allen
Journal of the American Chemical Society, 1930 , vol. 52, p. 2956
Organic Syntheses, 1943 , vol. Coll. Vol. II, p. 228
反应条件
1: ethanol; Na2S2 2: zinc; aqueous acetic acid View Scheme
参考文献
Hodgson; Dodgson
Journal of the Chemical Society, 1948 , p. 1002
反应条件
1: diluted alcohol View Scheme
参考文献
Allen
Journal of the American Chemical Society, 1930 , vol. 52, p. 2956
Organic Syntheses, 1943 , vol. Coll. Vol. II, p. 228
反应条件
sodium hydride in N,N-dimethyl-formamide T=0 - 20°C; 2 h;
参考文献
ACTELION PHARMACEUTICALS LTD.
Patent: US2009/105232 A1, 2009 ;
Location in patent: Page/Page column 31 ;
US 20090105232 A1
反应条件
1: 2-Mercaptothiophene With sodium hydroxide in ethanol; water 2: 1-chloro-2,4-dinitro-benzene in ethanol; water 0.25 h; Heating / reflux;
参考文献
GUILFORD PHARMACEUTICALS INC.
Patent: WO2005/53609 A2, 2005 ;
Location in patent: Page/Page column 22 ;
WO 2005/053609 A2
反应条件
18-crown-6 ether in acetonitrile Arylation; 6 h; Heating;
参考文献
Rozhkov; Chervin; Prosyanik; Kostyanovsky
Russian Chemical Bulletin, 1996 , vol. 45, # 12 p. 2876 - 2877
反应条件
ammonium hydroxide in formamide T=85°C; P=3000.2 - 3750.3 Torr; 4 h;
参考文献
Niclas, Hans-Joachim; Bohle, Matthias; Rick, Jens-Detlev; Zeuner, Frank; Zoelch, Lothar
Zeitschrift fuer Chemie (Stuttgart, Germany), 1985 , vol. 25, # 4 p. 137 - 138
反应条件
tetra-n-butylammonium tetrafluoroborate in N,N-dimethyl-formamide T=10°C; Electrolysis;
参考文献
Journal of Organic Chemistry, , vol. 67, # 8 p. 2548 - 2555
