1-氯-2,4-二硝基苯合成路线 （共 755 条）
反应条件
1: 2,4,6-trinitro-phenol With sodium hydroxide; Tulsion A-27 in water
Solid phase reaction; deprotonation; 1 h;
2: 1-chloro-2,4-dinitro-benzene in acetonitrile
T=25°C; Solid phase reaction; substitution; 0.166667 h;
参考文献
Bandgar; Dhakne; Nigal
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999 , vol. 38, # 1 p. 111 - 113
反应条件
1: 95 percent / acetonitrile / 72 h / Heating
2: ethanol; H2O / 24 h / 20 °C
View Scheme
参考文献
Kamogawa, Hiroyoshi; Sato, Shigeki
Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 1 p. 321 - 323
反应条件
1: 97 percent / acetonitrile / 72 h / Heating
2: 83 percent / ethanol; H2O / 25 h / 20 °C
View Scheme
参考文献
Kamogawa, Hiroyoshi; Sato, Shigeki
Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 1 p. 321 - 323
反应条件
triethylamine in acetone
T=20°C; 2 h;
参考文献
SIRTRIS PHARMACEUTICALS, INC.
Patent: WO2009/146358 A1, 2009 ;
Location in patent: Page/Page column 87 ;
WO 2009/146358 A1
反应条件
1: aqueous NaOH-solution
2: sulfuric acid; nitric acid
View Scheme
参考文献
Desseigne
Memorial des Poudres, 1949 , vol. 31, p. 43,44
参考文献
Bost; Turner; Conn
Journal of the American Chemical Society, 1933 , vol. 55, p. 4956
反应条件
sodium hydroxide in water; acetonitrile
T=25°C;
参考文献
Bunton, Clifford A.; Gan, Leong-Huat; Savelli, Gianfranco
Journal of Physical Chemistry, 1983 , vol. 87, # 26 p. 5491 - 5498
反应条件
sodium hydroxide in water; acetonitrile
T=25°C; micellar reaction; effect of NaOH; Rate constant;
参考文献
Bunton, Clifford A.; Gan, Leong-Huat; Savelli, Gianfranco
Journal of Physical Chemistry, 1983 , vol. 87, # 26 p. 5491 - 5498
反应条件
sodium hydroxide; 1,1-dimethylpropan-1-ol; octane; water
T=25°C; var. composition of emulsion, var. cosurfactant alcohol; Rate constant;
参考文献
Bunton, Clifford A.; de Buzzaccarini, Francesco de; Hamed, Fareed H.
Journal of Organic Chemistry, 1983 , vol. 48, # 15 p. 2461 - 2465
参考文献
Talukdar,P.B. et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1976 , vol. 14, p. 382 - 384
