2-硝基-4-甲砜基氯苯合成路线 （共 15 条）
反应条件
1: malonic acid dimethyl ester With potassium tert-butylate in tert-butyl alcohol
2: 4-methylsulfonyl-2-nitrochlorobenzene in tert-butyl alcohol
T=20°C; 15 h; Heating / reflux;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/9465 A1, 2008 ;
Location in patent: Page/Page column 91 ;
US 20080009465 A1
反应条件
1: NaOH
2: urea / 200 °C
3: aq. NaOH
View Scheme
参考文献
Lavrishchev,V.A. et al.
J. Gen. Chem. USSR (Engl. Transl.), 1960 , vol. 30, # 9 p. 3064 - 3072,3037 - 3044
反应条件
1: ethanol / 18 h / Ambient temperature
2: KOH / ethanol / 44 h
3: 1.) Zn, HCl, 2.) NaOH, O2 / 1.) CH3COOH, 60 deg C, 1 h, 2.) water, ethanol, 4 h
View Scheme
参考文献
Singh; Patrick
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 4 p. 995 - 999
反应条件
(i) Na2S3, (ii) /BRN= 1098293/, (iii) SO2Cl2; Multistep reaction;
参考文献
Bouanane,A. et al.
Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1976 , vol. 283, p. 319 - 321
反应条件
1: ethanol / 18 h / Ambient temperature
2: KOH / ethanol / 44 h
3: 1.) Zn, HCl, 2.) NaOH, O2 / 1.) CH3COOH, 60 deg C, 1 h, 2.) water, ethanol, 4 h
4: Na2S2O4 / H2O
View Scheme
参考文献
Singh; Patrick
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 4 p. 995 - 999
