L-苹果酸合成路线

EXELIXIS, INC.; WILSON, Jo, Ann; NAGANATHAN, Sriram; PFEIFFER, Matthew; ANDERSEN, Neil, G.
Patent: WO2013/59788 A1, 2013 ;
Location in patent: Paragraph 0070; 0071; 0072 ;

97-67-6L-苹果酸

32233-44-6(4S)-2,2-二甲基-1,3-二氧戊环-4-乙醛

参考文献

Nakata; Saito; Oishi
Tetrahedron Letters, 1986 , vol. 27, # 52 p. 6341 - 6344

97-67-6L-苹果酸+

67-64-1丙酮

32233-44-6(4S)-2,2-二甲基-1,3-二氧戊环-4-乙醛

参考文献

Hanessian, Stephen; Ugolini, Antonio; Therien, Michel
Journal of Organic Chemistry, 1983 , vol. 48, # 23 p. 4427 - 4430

67-56-1甲醇+

97-67-6L-苹果酸

617-55-0L-苹果酸二甲酯

参考文献

Nagano, Masanobu; Tanaka, Masakazu; Doi, Mitsunobu; Demizu, Yosuke; Kurihara, Masaaki; Suemune, Hiroshi
Organic Letters, 2009 , vol. 11, # 5 p. 1135 - 1137

97-67-6L-苹果酸+

149-73-5原甲酸三甲酯

617-55-0L-苹果酸二甲酯

参考文献

Zurwerra, Didier; Glaus, Florian; Betschart, Leo; Schuster, Julia; Gertsch, Juerg; Ganci, Walter; Altmann, Karl-Heinz
Chemistry - A European Journal, 2012 , vol. 18, # 52 p. 16868 - 16883

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