1: chloroacetaldehyde dimethyl acetal With toluene-4-sulfonic acid in ethanol; water T=20 - 65°C; 2: With sodium hydrogencarbonate in ethanol; water T=20°C; pH=7; 3: 6-amino 2-chloro pyridine in ethanol; water 3 h; Reflux;
参考文献
EVOTEC NEUROSCIENCES GMBH
Patent: WO2009/135842 A1, 2009 ;
Location in patent: Page/Page column 80 ;
WO 2009/135842 A1