反应条件
1.1: pyridine / 3 h / 0 °C 2.1: sodium ethanolate / 2 h / 20 °C 2.2: 28 h / 20 - 78 °C 3.1: sodium hydride / N,N-dimethyl-formamide / 40 °C 3.2: 3 h / 80 °C 4.1: potassium hydroxide / ethanol / Reflux 5.1: 1 h / 130 °C / Neat (no solvent) 6.1: (S)-1-phenyl-ethylamine / diethyl ether / 1 h / 20 °C 6.2: 0 °C / pH 1 7.1: potassium carbonate / water; toluene / 0.5 h / 20 °C 7.2: 90 °C 8.1: water; acetone / 5 °C / Reflux View Scheme
参考文献
Hao, Jia; Chen, Bo; Yao, Yiwu; Hossain, Murad; Nagatomo, Takafumi; Yao, Hequan; Kong, Lingyi; Sun, Hongbin
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 10 p. 3441 - 3444
